北华大学学报（自然科学版）2025，Vol.26Issue(3)：340-344,5.DOI:10.11713/j.issn.1009-4822.2025.03.010
抗VEGF联合靶向视网膜光凝术对糖尿病性黄斑水肿的临床疗效
Clinical Effect of Anti-VEGF Combined with Targeted Retinal Photocoagulation in Diabetic Macular Edema
摘要
Abstract
Objective To evaluate the efficacy of anti-VEGF(vascular endothelial growth factor)intraocular injections combined with targeted retinal photocoagulation(TRP)in the treatment of diabetic macular edema(DME).Methods Sixty patients(60 eyes)with severe NPDR/mild PDR(stages Ⅲ and Ⅳ)complicated with diabetic macular edema(DME)were selected and randomly divided into group A and group B according to the order of enrollment.Group A had 30 patients(30 eyes)and group B had 30 patients(30 eyes).Group A patients received 0.05 mg of Conbercept injection once a month via intraocular injection,followed by on-demand injection after 3 consecutive months.Group B patients received 0.05 mg of Conbercept injection once a month via intraocular injection,followed by on-demand injection after 3 consecutive months,and in combination with TRP after the 1st injection.Visual acuity examination,optical coherence tomography(OCT),and fluorescein fundus angiography(FFA)were used to observe changes in best corrected visual acuity(BCVA)and central macular thickness(CMT)before treatment and at 1,3 and 6 months after treatment.Enzyme linked immunosorbent assay(ELISA)was used to measure changes in VEGF levels in the serum of patients before treatment and at 3 and 6 months after treatment.Results At 1,3 and 6 months after treatment,compared with before treatment,both groups of patients showed an improvement in best corrected visual acuity(BCVA)and a decrease in retinal CMT(both P＜0.05).Compared with group A,patients in group B showed a significant increase in BCVA and a significant decrease in CMT(both P＜0.05).At 3 and 6 months after treatment,compared with before treatment,the levels of VEGF in peripheral blood of both groups of patients were significantly reduced(P＜0.05).Compared with group A,group B showed a significant decrease in VEGF levels(P＜0.05).The total number of in-jections in group A was(4.57±1.01),while the total number of injections in group B was(4.03±0.85).Com-pared with group A,the number of injections in group B was significantly reduced(P＜0.05).During the follow-up period,2 patients in group A progressed to the proliferative phase,while none of the patients in group B pro-gressed to the proliferative phase.Conclusion The combination of anti-VEGF therapy and TRP can effectively improve the visual acuity of DME patients,delay the progression of DR,reduce the need for anti-VEGF injection,and may be considered for DME patients with concomitant retinal neovascularization or poor compliance.关键词
靶向视网膜光凝术/抗VEGF/糖尿病性黄斑水肿Key words
targeted retinal photocoagulation/anti-VEGF/diabetic macular edema分类
临床医学引用本文复制引用
桑英旗,张富程,张睿,季芯羽,卢奕安,冷瀛..抗VEGF联合靶向视网膜光凝术对糖尿病性黄斑水肿的临床疗效[J].北华大学学报（自然科学版）,2025,26(3):340-344,5.基金项目
吉林省教育厅科学技术研究项目(JJKH20240095KJ) （JJKH20240095KJ）
吉林省自然科学基金项目(20200201495JC). （20200201495JC）
