北华大学学报（自然科学版）2025，Vol.26Issue(3)：345-349,5.DOI:10.11713/j.issn.1009-4822.2025.03.011
肿瘤标志物与中性粒细胞/淋巴细胞对直肠癌早期诊断价值
Early Diagnostic Value of Tumor Markers and Neutrophil/Lymphocyte in Rectal Cancer
摘要
Abstract
Objective To explore the differences in tumor markers and Neutrophil to lymphocyte ratio(NLR)between benign and malignant rectal tumors,and to identify indicators that are meaningful for the early diagnosis of rectal cancer.Methods 126 patients with rectal cancer and 92 patients with benign rectal tumors were selected.Relevanted tumor markers Carcinoembryonic antigen(CEA),Cytokerantin-fragment-19(CYFRA21-1),Ferritin(Ferr),Carbohydrate antigen199(CA199),Carbohydrate antigen724(CA724)levels,and preoperative NLR levels.Analyzed the differences of each index between the two groups,and established binary Logistic regression models for the indexes with differences,and plotted the Receiver Operating Characteristic(ROC)curves,and performed correlation analysis of each index.Results The levels of age,CEA,CYFRA21-1 and NLR of patients in malignant group were higher than those in benign group,and the level of Ferr of patients in malignant group was lower than that in benign group,with statistical significance(P＜0.05).CEA,CYFRA21-1 and NLR were risk factors for rectal cancer,and the Odds Ratio(OR)were 1.255(95％CI:1.088～1.446,P=0.002),1.602(95％CI:1.143～2.245,P=0.006)and 1.739(95％CI:1.003～3.015,P=0.049),respectively.Ferr was a protective factor for rectal cancer,and the OR value was 0.996(95％CI:0.993～0.998,P=0.001).The predictive probabilities of CEA,CYFRA21-1,Ferr and NLR for rectal cancer were 74.1％,69.2％,72.7％,65.0％,respec-tively.The prediction probability of the combination of the four was 83.7％.The sensitivity and specificity of com-bined detection of four markers were 0.776 and 0.773,respectively.There was a positive correlation between NLR/CEA and NLR/CYFRA21-1(P＜0.05),and the rest were not statistically significant(P＞0.05).Conclusion There are differences in the levels of CEA,CYFRA21-1,Ferr and NLR between benign and malignant rectal tumors.The combined detection of the four had some clinical value for the early diagnosis of rectal cancer.关键词
直肠癌/癌胚抗原/细胞角质素片段19/铁蛋白/中性粒细胞/淋巴细胞Key words
rectal cancer/Carcinoembryonic antigen/Cytokeratin-fragment-19/Ferritin/Neutrophil to lymphocyte ratio分类
医药卫生引用本文复制引用
李秀娟,南京柱,魏雪梅,鲁鸿昊,王雪敏,李蓉,张旭..肿瘤标志物与中性粒细胞/淋巴细胞对直肠癌早期诊断价值[J].北华大学学报（自然科学版）,2025,26(3):345-349,5.基金项目
科技部国家重点研发计划项目(2021YFC1005300). （2021YFC1005300）
