北华大学学报（自然科学版）2025，Vol.26Issue(3)：350-354,5.DOI:10.11713/j.issn.1009-4822.2025.03.012
心型脂肪酸结合蛋白与超敏肌钙蛋白Ⅰ联合检测在急性心肌梗死早期诊断中的价值
Diagnostic Value of Combined h-FABP and hs-cTn Ⅰ in Early Detection of Acute Myocardial Infarction
摘要
Abstract
Objective To investigate the value of combined detection of heart-type fatty acid binding protein(h-FABP)and high-sensitivity cardiac troponin Ⅰ(hs-cTn Ⅰ)for early diagnosis within 6 hours of acute myocardial infarction(AMI).Methods Three hundred patients were divided into acute myocardial infarction(AMI),old myocardial infarction(OMI),and angina pectoris(AP)based on clinical diagnosis.In addition,a healthy control group was established.Calculation software was used to determine the cutoff value and Youden's index.The sensitivity and specificity of detecting the two indicators alone and in combination were compared in healthy and high-risk populations.The value of combined detection of h-FABP and hs-cTn Ⅰ for the early diagnosis of acute myocardial infarction was evaluated by using Receiver Operating Characteristic(ROC)curve analysis.Results The cutoff value and Youden's index of h-FABP were 7.030 and 0.624,respectively.The sensitivity and specificity of the combined detection of two indicators in all populations were 0.704 and 0.778,respectively,AUC=0.823.The sensitivity and specificity of the combined detection of h-FABP and hs-cTn Ⅰ in normal population were 0.776 and 0.980,respectively,AUC=0.933.The results of the joint detection of two indicators insuspicious population were also greater than those of any indicator detected separately(P＜0.05).Conclusion The combined detection of h-FABP and hs-cTn Ⅰ indicators can enhance the sensitivity and specificity of early diagnosis of AMI.This approach helps reduce the rates of missed diagnoses and misdiagnoses,thereby improving clinical diagnostic utility.关键词
心型脂肪酸结合蛋白/超敏肌钙蛋白Ⅰ/急性心肌梗死/陈旧性心肌梗死Key words
heart-type fatty acid binding protein/high-sensitivity cardiac troponin Ⅰ/acute myocardial infarction/old myocardial infarction分类
医药卫生引用本文复制引用
刘阳,吴翠翠,杨春雪,李彬先,刘丽..心型脂肪酸结合蛋白与超敏肌钙蛋白Ⅰ联合检测在急性心肌梗死早期诊断中的价值[J].北华大学学报（自然科学版）,2025,26(3):350-354,5.基金项目
吉林省教育厅科学技术研究项目(JJKH20240100KJ) （JJKH20240100KJ）
吉林省卫生健康科技能力提升项目(2023LC023) （2023LC023）
吉林市医疗卫生指导性计划项目(20220404033). （20220404033）
