吉林大学学报（医学版）2025，Vol.51Issue(2)：486-492,7.DOI:10.13481/j.1671-587X.20250223
TRIM24蛋白在人肾透明细胞癌组织中的表达及其临床意义
Expression of TRIM24 protein in human clear cell renal cell carcinoma tissue and its clinical significance
摘要
Abstract
Objective:To discuss the expression of tripartite motif-containing protein 24(TRIM24)in the clear cell renal cell carcinoma(ccRCC)tissue,and to clarify its relationships with the clinicopathological features and prognosis of the ccRCC patients.Methods:The cancer and paracancer normal tissues were collected from 90 ccRCC patients who had not undergone preoperative radiotherapy or chemotherapy.Tissue microarray and immunohistochemistry were used to detect the expression levels of TRIM24 protein in ccRCC tissue.The differences in TRIM24 protein expression between ccRCC and paracancer normal tissues were analyzed.The score of TRIM24 protein expression and the average value were calculated,and based on the average value,the patients were classified into TRIM24 protein low-expression and TRIM24 protein high-expression groups.The associations between the TRIM24 protein expression and different clinicopathological features of the patients were analyzed,and the relationship between the TRIM24 protein expression and the prognosis of the patients was analyzed.Results:The immunohistochemistry results showed that the TRIM24 protein was expressed in both the nucleus and cytoplasm of the ccRCC tumor cells,and there were significant differences in the TRIM24 protein expression level in ccRCC tissue when compared with paracancer normal tissue(P＜0.05).The TRIM24 protein expression in the nucleus of ccRCC tissue was associated with the patient's age,gender,and tumor size(P＜0.05).The Kaplan-Meier survival analysis results showed that the overall survivals of the patients with high TRIM24 protein expression in the cytoplasm of ccRCC tissue,older age,and higher pathological grade were shorter than those with low TRIM24 protein expression,younger age,and lower pathological grade(P＜0.05).The multivariate Cox regression analysis results showed that the prognosis of the patients with high TRIM24 protein expression in the cytoplasm and higher pathological grade were poorer compared with the patients with low TRIM24 protein expression and lower pathological grade(P＜0.05).Conclusion:The ccRCC patients with high TRIM24 expression in the cytoplasm of ccRCC tumor tissue and higher pathological grade have the lower postoperative survival rates and poorer prognosis.关键词
肾透明细胞癌/三重基序蛋白24/免疫组织化学/病理分级/预后Key words
Clear cell renal cell carcinoma/Triple motif protein 24/Immunohistochemistry/Pathological grade/Prognosis分类
医药卫生引用本文复制引用
耿海营,于焱,代春美,温有锋,李宁..TRIM24蛋白在人肾透明细胞癌组织中的表达及其临床意义[J].吉林大学学报（医学版）,2025,51(2):486-492,7.基金项目
辽宁省教育厅科研面上项目(LJKZ0811,JYTMS20231393) （LJKZ0811,JYTMS20231393）
辽宁省中央引导地方科技发展专项项目(2023JH6/100100021) （2023JH6/100100021）
