吉林大学学报（医学版）2025，Vol.51Issue(2)：526-533,8.DOI:10.13481/j.1671-587X.20250228
Hedgehog信号通路磷酸化修饰在肿瘤发生发展中作用的研究进展
Research progress in effect of phosphorylation modification of Hedgehog signaling pathway on occurrence and development of tumor
摘要
Abstract
The Hedgehog(HH)signaling pathway is involved in various developmental processes of vertebrates and invertebrates,including embryogenesis,stem cell renewal,tissue regeneration,the occurrence and development of tumor and chemotherapy resistance.Overactivation and abnormal expression of key components in the HH signaling pathway are associated with the development of various malignant tumors.Phosphorylation plays an important role in regulating the activity and function of proteins in normal cells,and the disorder of phosphorylation-dephosphorylation cascade is closely related to tumorigenesis.The abnormal activation of this signaling pathway is also related to protein phosphorylation,while its complex underlying mechanism needs to be further explored.This article reviewed the research progress of the HH signaling pathway and protein phosphorylation modification in malignant tumors,focusing on the regulatory effect of phosphorylation modification on the activity of HH signaling pathway and its effect on the occurrence and development of malignant tumors,in order to provide a theoretical basis for the in-depth development and clinical application of targeted drugs for phosphatase/dephosphatase.关键词
肿瘤/Hedgehog信号通路/蛋白磷酸酶/去磷酸化Key words
Tumor/Hedgehog signaling pathway/Protein phosphatase/Dephosphorylation分类
临床医学引用本文复制引用
张鑫,王飞,崔冰洁,杜静..Hedgehog信号通路磷酸化修饰在肿瘤发生发展中作用的研究进展[J].吉林大学学报（医学版）,2025,51(2):526-533,8.基金项目
国家自然科学基金项目(82373097,31900441) （82373097,31900441）
山东省科技厅自然科学基金项目(ZR2019MC026) （ZR2019MC026）
山东省卫健委中医药发展计划项目(2019-0514) （2019-0514）
泰山学者青年专家经费项目(tsqn202103191) （tsqn202103191）
