吉林大学学报（医学版）2025，Vol.51Issue(2)：534-540,7.DOI:10.13481/j.1671-587X.20250229
蛋白磷酸酶2A与肿瘤发生发展关系的研究进展
Research progress in relationship between protein phosphatase 2A and occurrence and development of tumor
摘要
Abstract
Protein phosphatase 2A(PP2A)is one of the major serine-threonine protein phosphatases in mammalian cells which plays an important role in regulating biological activities such as cellular mitosis and protein dephosphorylation.PP2A acts as a tumor suppressor and has been demonstrated to be genetically altered or functionally inactivated in a variety of solid cancers and leukemias,and its activity is inhibited,leading to subsequent proliferation of tumor cells.Clinical studies have shown that endogenous inhibitors such as SET,cancerous inhibitor of PP2A(CIP2A)and protein phosphatase methylesterase-1(PME-1)may reduce PP2A activity,which could be important indicators of tumor progression or recurrence.On the other hand,PP2A-activating drugs(e.g.FTY720)can restore the tumor-suppressing activity of PP2A by altering the structure of the inhibitor SET,thus effectively inhibiting tumor development.Therefore,PP2A and its inhibitors may serve as potential therapeutic targets in clinic.This article provides a comprehensive review on the mechanism of action of PP2A and its inhibitors in the pathogenesis of malignant tumor as well as their applications in oncotherapy,aiming to provide new directions for the treatment of malignant tumors.关键词
蛋白磷酸酶2A/内源性抑制剂/肿瘤/蛋白磷酸酶2A癌症抑制剂/蛋白磷酸酶甲基酯酶-1Key words
Protein phosphatase 2A/Endogenous inhibitor/Tumor/Cancerous inhibitor of protein phosphatase 2A/Protein phosphatase methylesterase-1分类
临床医学引用本文复制引用
张慧灵,郭文秀,孟峻..蛋白磷酸酶2A与肿瘤发生发展关系的研究进展[J].吉林大学学报（医学版）,2025,51(2):534-540,7.基金项目
国家自然科学基金项目(81360109,81660267) （81360109,81660267）
内蒙古自治区科技厅自然科学基金项目(2021MS08158) （2021MS08158）
