吉林大学学报（医学版）2025，Vol.51Issue(2)：479-485,7.DOI:10.13481/j.1671-587X.20250222
胰岛素样生长因子1与结直肠癌因果关系的两样本孟德尔随机化研究
Two sample Mendelian randomization study on causal relationship between insulin-like growth factor-1 and colorectal cancer
摘要
Abstract
Objective:To explore the causal association between insulin-like growth factor-1(IGF-1)and colorectal cancer(CRC)based on two sample Mendelian randomization(MR)analysis.Methods:A bidirectional two sample MR analysis was conducted based on publicly aggregated data from the IEU OpenGWAS project.The inverse variance weighted(IVW)method was used as the main analysis model to assess the causal relationship between IGF-1 and CRC.Additional analyses were performed using weighted median(WM),MR-Egger regression,weighted mode estimator(WME),and simple mode(SM)methods.Sensitivity analysis was performed to assess the robustness of the results.Results:A total of 386 single nucleotide polymorphisms(SNPs)were selected as instrumental variables(IVs)with IGF-1 as the exposure factor.The MR analysis results revealed a positive causal association between IGF-1 and the risk of CRC[odds ratio(OR)=1.178,95％confidence interval(CI):1.092-1.272)](P＜0.001),and the association remained significant after adjusting for height[OR(95％CI)=1.214(1.111,1.327)](P＜0.001).Cochran's Q-test showed heterogeneity among the IVs(P＜0.05),while the horizontal pleiotropy of IV was not detected by the MR-Egger regression(P＞0.05).The leave-one-out analysis showed that the MR results were robust.Reverse MR analysis indicated no reverse causal relationship between IGF-1 and CRC[OR(95％CI):1.017(0.997,1.037)](P=0.103).Conclusion:There is a causal relationship between IGF-1 level and CRC,and elevated IGF-1 level could be a risk factor for CRC.关键词
胰岛素样生长因子1/结直肠癌/孟德尔随机化/身高/单核苷酸多态性Key words
Insulin-like growth factor-1/Colorectal cancer/Mendelian randomization/Height/Single nucleotide polymorphism分类
医药卫生引用本文复制引用
穆华夏,王清华,孔雨佳,王素珍,卜伟晓,丁淑婷,高梦瑶,苏维强,张震,薄其付,刘峰,石福艳..胰岛素样生长因子1与结直肠癌因果关系的两样本孟德尔随机化研究[J].吉林大学学报（医学版）,2025,51(2):479-485,7.基金项目
国家自然科学基金青年项目(82003560) （82003560）
山东省科技厅自然科学基金面上项目(ZR2020MH340,ZR2023MH313) （ZR2020MH340,ZR2023MH313）
陕西省科技厅科技计划项目(2024SF-YBXM-256) （2024SF-YBXM-256）
山东省教育厅大学生创新创业基金项目(S202410438047) （S202410438047）
山东第二医科大学大学生创新创业基金项目(X2024374,X2024394) （X2024374,X2024394）
