磁共振成像2025，Vol.16Issue(4)：33-40,150,9.DOI:10.12015/issn.1674-8034.2025.04.006
DCE-MRI影像组学联合血细胞参数鉴别管腔型和非管腔型乳腺癌的价值
Value of radiomics model based on DCE-MRI combined with blood cell parameters in differentiating Luminal and Non-Luminal breast cancer
摘要
Abstract
Objective:To explore the value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)radiomics model combined with blood cell parameters in differentiating Luminal and Non-Luminal breast cancer(BC).Materials and Methods:DCE-MRI of two hundred and twenty-seven patients with pathologically confirmed BC were retrospectively analyzed.The patients were randomly split into a training set(n=162)and a validation set(n=65)at a ratio of 7∶3.Patients were divided into the Luminal group(139 cases)and the Non-Luminal group(88 cases)according to the immunohistochemical results.The BC lesions on the pretreatment DCE-MRI served as the basis for the volume of interest for feature extraction.Three models were constructed to differentiate Luminal from Non-Luminal by analyzing radiomic feature,clinical pathological feature,and hematological parameters.These models were Model 1(radiomics),Model 2(hematological parameters),and Model 3(radiomics+hematological parameters),respectively.The discrimination performance of the models was evaluated using the receiver operating characteristic curve.Decision curve analysis was conducted to determine the clinical usefulness of the models by quantifying the net benefits at different threshold probabilities.Results:The area under the curve(AUC),sensitivity,and specificity,of Model 3 were 0.840(0.774 to 0.893),87.9%,and 71.4%in the training set,and 0.818(0.703 to 0.903),87.5%,and 68.0%in the validation set,respectively.The AUC of the Model 1 was better than that of the Model 2 in the both cohorts(0.817 vs.0.636,0.838 vs.0.515,P=0.001 and P<0.001),and the AUC of the Model 3 was also better than that of the Model 2 in the both cohorts(0.840 vs.0.636,0.818 vs.0.515,both P<0.001).The Model 3 and Model 1 were both more beneficial than Model 2 in clinical practice,as illustrated by decision curve analysis.Conclusions:The model that integrated the hematological parameters with DCE-MRI radiomics can help differentiate Luminal from Non-Luminal BC,which facilitates the accurate treatment planning for BC.关键词
管腔型乳腺癌/非管腔型乳腺癌/磁共振成像/影像组学/血细胞参数/诊断价值Key words
Luminal breast cancer/Non-Luminal breast cancer/magnetic resonance imaging/radiomics/hematological parameters/diagnostic value分类
医药卫生引用本文复制引用
胥豪,杨澳,胡云涛,周鹏,邓和平..DCE-MRI影像组学联合血细胞参数鉴别管腔型和非管腔型乳腺癌的价值[J].磁共振成像,2025,16(4):33-40,150,9.基金项目
National Natural Science Foundation of China(No.U21A20521). 国家自然科学基金项目(编号:U21A20521) （No.U21A20521）
