磁共振成像2025，Vol.16Issue(4)：48-53,6.DOI:10.12015/issn.1674-8034.2025.04.008
三维酰胺质子转移成像在预测肝细胞癌病理分级中的初步研究
Preliminary study of three-dimensions amide proton metastasis imaging in the prediction of pathological grade of hepatocellular carcinoma
摘要
Abstract
Objective:To explore the value of three-dimensional amide proton transfer weighted(3D-APTw)imaging in the assessment of the pathological grade of hepatocellular carcinoma(HCC).Materials and Methods:A total of 43 patients with surgical pathology confirmed HCC from October 2020 to April 2023 and underwent Edmondson-Steiner grade(grade Ⅰ to Ⅳ)were prospectively recruited.We classified grade Ⅰ and Ⅱ HCC as low grade HCC and grade Ⅲ and Ⅳ lesions as high grade HCC.A Philips 3.0 T MRI device was scanned before surgery to acquire T1WI,T2WI,diffusion-weighted imaging,amide proton transfer weighted(APTw)and multi-stage enhanced images,respectively.APTw values for HCC and hepatplasm were measured independently by two experienced radiologists.Differences between groups were analyzed by the Mann-Whitney U non-parametric test.The diagnostic efficacy of APTw value was analyzed using the receiver operating characteristic(ROC)curve,and the area under the curve(AUC),threshold,sensitivity and specificity were calculated.A Spearman correlation analysis was used to assess the association between APTw and the histological grade of HCC.Results:The APTw value of low grade HCC(2.15%±0.13%)was significantly lower than that of high grade HCC(2.63%±0.13%),and the difference was statistically significant(P=0.03).The AUC for identifying high grade and low grade HCC was 0.69(95%CI:0.53 to 0.82),and with an optimal threshold of 1.85%,the sensitivity and specificity were 90.00%and 42.31%,respectively.Spearman results of the correlation analysis showed a positive correlation between APTw value and HCC pathological grade,with a correlation coefficient of r=0.43(P=0.003).Conclusions:The APTw value can be used to identify high grade and low grade HCC,and the 3D-APTw imaging has some value in predicting the preoperative pathological grade of HCC.关键词
酰胺质子转移成像/肝细胞癌/病理分级/功能磁共振成像Key words
amide proton transfer imaging/hepatocellular carcinoma/histologic grades/functional magnetic resonance imaging分类
医药卫生引用本文复制引用
齐晓辉,杜煜,王琦,沈智威,段梦婷,刘响,潘江洋,王丽佳,贾丽涛,王亚宁..三维酰胺质子转移成像在预测肝细胞癌病理分级中的初步研究[J].磁共振成像,2025,16(4):48-53,6.基金项目
Medical Science Research Project of Hebei(No.20221276). 河北省医学科学研究课题计划项目(编号:20221276) （No.20221276）
