大连理工大学学报2025，Vol.65Issue(3)：243-248,6.DOI:10.7511/dllgxb202503004
槲皮素下调OLA1基因抑制AKT通路增强胰腺癌对药物敏感性
Quercetin down-regulates OLA1 gene to inhibit AKT pathway and enhance drug sensitivity of pancreatic cancer
摘要
Abstract
Gemcitabine causes drug resistance in the treatment of pancreatic cancer,which affects the efficacy,and there is no effective way to solve it.As a common anti-inflammatory and anti-cancer drug,quercetin has a good pharmacodynamic value and a non-negligible impact on the treatment of tumors.OLA1 belongs to the GTPase family of the Obg class and plays an important role in the growth of tumors.In order to explore whether quercetin can improve the drug resistance of gemcitabine and find the potential mechanism of action and targets,experiment prediction is conducted by network pharmacology,and the results show that there are 60 triple intersection targets,among which p-AKT,EGFR and HSP90AA1 are identified as the main targets.It is proved by experiments that quercetin combined with gemcitabine can enhance the therapeutic effect of pancreatic cancer,significantly inhibit the growth level of cells,reduce the expression levels of OLA1 and p-AKT in pancreatic cancer cell lines,and the therapeutic effect of quercetin combined with gemcitabine in pancreatic cancer is reduced significantly when the OLA1 gene in pancreatic cancer cell lines is knocked down.关键词
槲皮素/胰腺癌/吉西他滨/耐药性/OLA1Key words
quercetin/pancreatic cancer/gemcitabine/drug resistance/OLA1分类
临床医学引用本文复制引用
刘漪铭,肖桂山..槲皮素下调OLA1基因抑制AKT通路增强胰腺癌对药物敏感性[J].大连理工大学学报,2025,65(3):243-248,6.基金项目
国家自然科学基金资助项目(81770846). （81770846）
