动物医学进展2025，Vol.46Issue(6)：70-76,7.
兔创伤性膝骨关节炎3种造模方法对比分析
Comparison and Analysis of Three Kinds of Modeling Methods for Traumatic Knee Osteoarthritis in Rabbits
摘要
Abstract
A rabbit KOA model based on worn joints was established,which was compared with two classi-cal traumatic modeling methods to provide a new choice for constructing a suitable animal model of KOA.Eighteen adult male New Zealand rabbits were randomly divided into modified Hulth group(n=6),ACLT combined MMT group(n=6)and joint wear group(n=6).After surgical modeling,skin temperature,be-havioral score,ELISA,imaging,blood routine examination,apparent observation and histopathological ex-amination were evaluated at each time point.Compared with the other two classical modeling methods,the behavioral scores of the joint wear group were significantly higher than those of the other groups except for 14 days(P＜0.05).WBC and Mankin's scores were significantly higher than those of other groups(P＜0.05);Imaging examination and apparent observation showed serious articular surface wear,cartilage loss,and obvious exposure of subchondral bone.Serum BALT and BGP levels of experimental rabbits at 14 and 28 days were significantly higher than those of other groups(P＜0.05),PICP levels at 28 days were signif-icantly higher than those of improved Hulth group(P＜0.05),and bone metabolism showed a high conver-sion type.Using joint wear method to establish rabbit KOA model has the advantages of stability,short modeling period and easy operation,which is conducive to the study of the etiology and pathological mecha-nism of KOA.关键词
兔/创伤性膝骨关节炎/动物模型Key words
Rabbit/Traumatic knee osteoarthritis/Animal model分类
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单爱婷,黄诗蕊,肖娅琪,张之盈,黎锦英,石达友..兔创伤性膝骨关节炎3种造模方法对比分析[J].动物医学进展,2025,46(6):70-76,7.基金项目
广东省高校质量工程建设项目-科产教融合实践教学基地项目[粤教高函(2021)29号] （2021）
