动物医学进展2025，Vol.46Issue(6)：97-104,8.
凝集素Griffithsin抗冠状病毒作用的研究进展
Progress on Lectin Griffithsin in Anti-coronavirus Infection
摘要
Abstract
Coronaviruses(CoVs)have attracted widespread attention due to their serious threat to human and animal health.Griffithsin(GRFT)has become a scientific hotspot due to its antiviral properties in combating coronavirus infection.This review focused on the glycosylation of coronavirus envelope proteins,the structural characteristics of GRFT and its antiviral mechanism,summarized the research progress of GRFT on human and animal coronaviruses,and analyzed the advantages and challenges of GRFT as a po-tential anti-coronavirus drug.In the future,the combination of multiple antiviral components and the opti-mization of GRFT delivery system will further enhance its application potential in human clinic and veteri-nary fields.In addition,combined with gene editing technology,it is expected to reduce the production cost and improve the therapeutic effect of GRFT,providing new strategies and methods for global prevention and control of coronavirus diseases.关键词
格瑞弗森/冠状病毒/刺突蛋白/糖基化修饰/抗病毒感染Key words
Griffithsin/Coronavirus/Spike protein/Glycosylation/Antiviral infection分类
农业科技引用本文复制引用
梅朋,黄晓紫,周炫汝,崔红杰,吴异健,刘萍..凝集素Griffithsin抗冠状病毒作用的研究进展[J].动物医学进展,2025,46(6):97-104,8.基金项目
福建农林大学科技创新专项基金项目(CXZX2020056A) （CXZX2020056A）
福建省自然科学基金项目(2021J01082) （2021J01082）
