分析测试学报2025，Vol.44Issue(5)：853-859,867,8.DOI:10.12452/j.fxcsxb.241023476
超高效合相色谱-质谱法快速分离和检测苯乙胺类物质异构体
Rapid Separation and Detection of Phenethylamines Isomers by Ul-tra Performance Convergence Chromatography-Mass Spectrometry
摘要
Abstract
Phenethylamines are widely abused currently as a class of new psychoactive substances(NPS).They are characterized by a wide variety of types,high potential harm and the presence of a large number of isomers.The structure and properties of these isomers are very similar,and thus pose great challenges for their accurately distinguishment and identification.In this study,an ultra performance convergence chromatography-mass spectrometry method for the rapid separation and de-tection of phenethylamines positional isomers and carbon chain isomers was established by using a Waters ACQUITY UPC2 BEH column,supercritical fluid CO2 as primary mobile phase,20 mmol/L ammonium formate in methanol as modifier and the column temperature at 60℃.Basic or baseline separation of 12 isomers could be achieved within 8.0 minutes.The limit of detection was between 0.02-0.5 ng/mL and the relative standard deviations of retention time were less than 0.30%.Com-pared with conventional ultra-high performance liquid chromatography-mass spectrometry method,this method is much better in the separation efficiency of isomers,which provides a new means for the accurate qualitative analysis of phenethylamines.关键词
超高效合相色谱/质谱/苯乙胺类/异构体/新精神活性物质Key words
ultra performance convergence chromatography/mass spectrometry/phenethyl-amines/isomers/new psychoactive substances分类
化学引用本文复制引用
胡爽,武磊,黄钰,姚晓飞,花镇东..超高效合相色谱-质谱法快速分离和检测苯乙胺类物质异构体[J].分析测试学报,2025,44(5):853-859,867,8.基金项目
北京市公安局科研项目(2024CX27017) （2024CX27017）
