分析测试学报2025，Vol.44Issue(5)：860-867,8.DOI:10.12452/j.fxcsxb.241015468
顶空-气相色谱-质谱法测定防晒类化妆品中16种苯系物
Determination of 16 Benzene Series in Sunscreen Cosmetics by Headspace-Gas Chromatography-Mass Spectrometry
摘要
Abstract
In this study,a method for the detection of 16 benzene series in sunscreen cosmetics was established based on headspace-gas chromatography-mass spectrometry(HS-GC-MS).The samples were dispersed with methanol and diluted with water,then equilibrated at 80℃for 40 min.The sam-ples were separated on a HP-5MS capillary column(30 m×0.25 mm×0.25 μm),then detected by GC-MS in selected ion monitoring mode(SIM).Toluene-D8 and 1,2-dichlorobenzene-D4 were used as internal standards and matrix matching curves were used for quantitative analysis.The results showed good linearity(r≥0.997 4)for 16 benzene series in corresponding concentration ranges.The limits of detection were in the range of 0.02-0.06 μg∙g-1.The average recoveries of two substrates at three different spiked levels ranged from 90.0%to 103%,with the relative standard deviations(RSDs)ranged from 0.20%to 6.5%.The method was used to detect 60 batches of sunscreen cosmetics,ben-zene series were detected in 39 batches of samples,among which the detection rates of m-xylene&p-xylene,o-xylene,toluene and ethylbenzene were 45%,32%,16%and 16%,respectively.Ben-zene was detected in five batches of sunscreen spray products,with content exceeding the limit(2.0 mg∙kg-1)in the"Safety and Technical Standards for Cosmetics"(2015 edition).The content of o-xylene,1,3,5-tritylene and m-xylene&p-xylene in some samples exceeded 2.0 mg∙kg-1.The method is simple,rapid,sensitive and accurate,which can be used for the determination of 16 ben-zene series in sunscreen cosmetics.关键词
顶空-气相色谱-质谱法/化妆品/苯系物/含量测定Key words
headspace-gas chromatography-mass spectrometry/cosmetics/benzene series/con-tent determination分类
化学化工引用本文复制引用
卢端萍,程佳华,洪清玲,陈旭,陈硕,简育莹,郑景峰,陈在敏..顶空-气相色谱-质谱法测定防晒类化妆品中16种苯系物[J].分析测试学报,2025,44(5):860-867,8.基金项目
福建省药品监督管理局科技项目(2023019) （2023019）
