分析测试学报2025，Vol.44Issue(5)：899-905,7.DOI:10.12452/j.fxcsxb.240924413
基于EEMD-airPLS方法的质谱信号处理研究
Research on Mass Spectrometry Signal Processing Based on EEMD-airPLS Method
摘要
Abstract
The miniature mass spectrometer have become a hot research direction in the field of mass spectrometry,featuring direct on-site testing,rapid analysis speed,and strong portability.It has widespread applications in biomedical and food safety fields.However,due to factors such as sample pretreatment and the usage environment,issues like high signal noise and severe baseline drift often arise when handling complex matrices(e.g.,blood samples),significantly reducing the accuracy and stability of detection results in practical applications.The ensemble empirical mode decomposi-tion(EEMD)method can adaptively decompose different physically meaningful characteristic compo-nents from the signals of miniature mass spectrometers,while the adaptive iteratively reweighted pe-nalized least squares(airPLS)method can further process the background baseline of the signals.The combined use of these two methods can significantly improve the accuracy and stability of the signals.Using a miniature mass spectrometer,mass spectrometric signals of α-hydroxy pentanedioic acid and γ-aminobutyric acid were obtained from actual blood samples and processed with the EEMD-air-PLS method,resulting in a significant improvement in the correlation coefficient(r²)and relative standard deviation(RSD),greatly enhancing the usability of data in actual blood sample testing.This approach provides a novel way for processing mass spectrometer signals,greatly expanding the application range of miniature mass spectrometers.关键词
小型质谱仪/信号分析与处理/EEMD-airPLS方法/血液样品Key words
miniature mass spectrometer/signal analysis and processing/EEMD-airPLS method/blood samples分类
化学化工引用本文复制引用
解滨瑞,巨子晟,詹陈锐,马强,李明..基于EEMD-airPLS方法的质谱信号处理研究[J].分析测试学报,2025,44(5):899-905,7.基金项目
国家重点研发计划(2023YFF0723500) （2023YFF0723500）
