分析化学2025，Vol.53Issue(4)：493-504,12.DOI:10.19756/j.issn.0253-3820.251058
基于微流控芯片的可穿戴多通道汗液传感器研究进展
Advances in Wearable Multi-Channel Sweat Sensor Based on Microfluidic Chip
摘要
Abstract
In situ continuous monitoring technology based on sweat detection can reflect the changes of human metabolic status,electrolyte balance and disease markers in real time,which can provide important dynamic data support for personalized health management,but it still faces bottlenecks such as lack of reliability of sweat sampling,high cross-interference among markers,and difficulty of dynamic continuous monitoring.Wearable sweat sensors based on microfluidic chips can effectively improve the detection accuracy of sweat markers by means of precise fluidic manipulation,multi-channel parallel analysis architecture,and chip surface functionalization modification techniques,providing a powerful tool for revealing the mysteries of human physiology at molecular level,and showing great potential for application in the field of personalized health monitoring.This paper focused on microfluidic chip-based multi-channel sweat sensors,and reviewed the recent progresses of microfluidic chips in sweat collection capability,wearable sensing implementation,and artificial intelligence technique synergizing to achieve simultaneous multi-parameter detection of sweat from the perspective of multi-channel synergistic sensing.Meanwhile,for industrialization bottlenecks such as crosstalk of sensing signals and wireless energy supply,this paper explored feasible solutions and technical routes,providing a theoretical framework and development direction for construction of a next-generation intelligent sweat monitoring system.By summarizing the practical needs in this field through an overview,this paper aimed to provide theoretical references and practical guidance for the development of more efficient wearable microfluidics.关键词
微流控技术/多通道检测/汗液传感/可穿戴/评述Key words
Microfluidics/Multichannel detection/Sweat sensing/Wearable/Review引用本文复制引用
吴冠潽,鲁洋,徐琳..基于微流控芯片的可穿戴多通道汗液传感器研究进展[J].分析化学,2025,53(4):493-504,12.基金项目
国家自然科学基金项目((Nos.62474078,U22A20184)、吉林省自然科学基金项目(No.20220201093GX)、中国博士后基金项目(No.2024T170324)、山东省自然科学基金项目(No.ZR2024MF026)和中央高校基本科研业务费项目资助. Supported by the National Natural Science Foundation of China(Nos.62474078,U22A20184),the Jilin Province Natural Science Foundation,China(No.20220201093GX),the China Postdoctoral Science Foundation(No.2024T170324),the Shandong Provincial Natural Science Foundation(No.ZR2024MF026)and the Fundamental Research Funds for the Central Universities. （(Nos.62474078,U22A20184）
