分析化学2025，Vol.53Issue(4)：568-578,11.DOI:10.19756/j.issn.0253-3820.241433
常压离子热诱导解离技术的研究
Research of Atmospheric Pressure Ion Heat Induced Dissociation Technology
摘要
Abstract
In the field of substance detection,ion dissociation techniques have become crucial for enhancing qualitative accuracy.By applying external energy to induce dissociation of ions in the substance being analyzed,the internal structural information can be obtained,thereby improving qualitative capabilities.Current research on ion dissociation techniques primarily focuses on tandem mass spectrometry,which typically requires a vacuum environment.However,research on ambient ion dissociation techniques is less developed,with some progress made in the field of tandem ion mobility spectrometry.Recently,the development of field-induced dissociation(FID)in this area has enabled ambient dissociation of various explosive and volatile alcohol ions.Nevertheless,the limitation imposed by the maximum breakdown field of air restricts the energy of the electric field,making it challenging to dissociate ions with high energy requirements,such as those of drugs.To address this issue,in this work,an ambient heat-induced dissociation(HID)technique based on high temperatures was proposed,in which an ambient ion heat-induced dissociation unit was developed and integrated into a home-made ion trap mass spectrometer.Experiments were conducted on four representative drug samples,e.g.methamphetamine,heroin,cocaine,and ketamine.The parent ions mass spectra,low vacuum collision-induced dissociation(CID)mass spectra and ambient HID mass spectra for each sample were obtained.By analyzing and comparing the fragmentation products from ambient and low vacuum dissociation,the feasibility of the ambient HID technique was verified.This technique provided a method for ion dissociation in single mass analyzers without tandem mass spectrometry capability and offered a new research direction for the future development of tandem ion mobility spectrometry.关键词
常压离子热诱导解离/毒品/质谱/碎片离子Key words
Ambient heat-induced ion dissociation/Drug/Mass spectrometry/Fragmention ion引用本文复制引用
冼天信,赵天翼,田森,张允晶,何兴理,李鹏,李灵锋..常压离子热诱导解离技术的研究[J].分析化学,2025,53(4):568-578,11.基金项目
国家重点研发计划项目(No.2022YFC330090)、国家自然科学基金项目(No.21904091)和中央高水平医院临床科研业务费项目(No.BJ-2022-095)资助. Supported by the National Key Research and Development Program of China(No.2022YFC3300900),the National Natural Science Foundation of China(No.21904091)and the National High Level Hospital Clinical Research Funding(No.BJ-2022-095). （No.2022YFC330090）
