分析化学2025，Vol.53Issue(4)：621-630,10.DOI:10.19756/j.issn.0253-3820.251038
基于微流控工艺制备丙交酯乙交酯共聚物微球及其降解和释药特性分析
Preparation and In Vitro Degradation Characteristics Analysis of Poly(lactic-co-glycolide)Microspheres Based on Microfluidic Process
摘要
Abstract
Poly(lactic-co-glycolide)(PLGA)is a key excipient in long-acting sustained-release preparations,and its degradation properties directly affect the drug release behavior.In this study,PLGA microspheres were prepared by microfluidic techniques,and the morphology changes of the microspheres were observed by scanning electron microscopy(SEM).In alkaline environment,due to the accelerated hydrolysis of ester bonds,the surface of the microspheres was rapidly dissolved and eroded,and the degradation rate was significantly higher than that in acidic environment.High temperature accelerated the degradation of PLGA microspheres.Under neutral and alkaline conditions,the microspheres showed aggregation and adhesion.Under acidic conditions,the microspheres gradually decomposed into irregular fragments.The high ionic strength further promoted the surface corrosion of the microspheres,especially under extreme pH conditions.Simultaneously,PLGA microspheres encapsulating coumarin were prepared to simulate the microsphere formulation.The release rate of coumarin after degradation of the microspheres under different conditions was observed by measuring the absorbance with ultraviolet-visible spectrophotometry.The results were consistent with those of the blank microspheres.This study revealed that the degradation of PLGA microspheres was significantly pH-dependent,temperature sensitive and ion strength responsive.These findings not only helped to understand and optimize the long-term stability and controlled release performance of drug-carrying microspheres,but also provided a theoretical basis for further improvement of PLGA-based drug carrier design.关键词
丙交酯乙交酯共聚物/微流控/微球/环境因素/降解特性Key words
Poly(lactide-co-glycolide)/Microfluidic/Microsphere/Environmental factor/Degradation characteristic引用本文复制引用
王保成,施海蔚,袁耀佐,陈洪渊,马聪玉,王科,郑思彤,张晓艳,赵月梅,赵恂,潘建斌,高正松..基于微流控工艺制备丙交酯乙交酯共聚物微球及其降解和释药特性分析[J].分析化学,2025,53(4):621-630,10.基金项目
2023年度江苏省工业和信息产业转型升级专项资金项目、江苏省药品监督管理局科技计划项目(No.202320)和江苏省市场监督管理局科技计划项目(No.KJ2024050)资助. Supported by the Industry and Information Technology Department of Jiangsu Province,the Science Project of Jiangsu Medical Products Administration(No.202320)and the Science Project of Jiangsu Provincial Administration for Market Regulation(No.KJ2024050). （No.202320）
