分子影像学杂志2025，Vol.48Issue(4)：397-404,8.DOI:10.12122/j.issn.1674-4500.2025.04.01
弥漫大B细胞淋巴瘤患者化疗前后PET代谢脑网络的Hub节点和模块化的差异
Differences in Hub nodes and modularity of PET metabolic brain network in diffuse large B-cell lymphoma patients pre-and post-chemotherapy
摘要
Abstract
Objective To construct metabolic brain networks in patients with diffuse large B-cell lymphoma(DLBCL)before and after chemotherapy using 18F-FDG PET imaging,and investigate the effect of the disease and R-CHOP chemotherapy regimen on brain function by analyzing differences in hub nodes and modularity.Methods A total of 51 DLBCL patients who underwent whole-body 18F-FDG PET scans before and after chemotherapy at the Nuclear Medicine Department of the Second Hospital of Lanzhou University from June 2021 to July 2024 were included retrospectively,along with 30 age-and sex-matched healthy controls.Inter-regional brain correlations were calculated using the Pearson correlation coefficient to construct the metabolic brain network.Graph theory-based analysis and 1000 permutation tests were subsequently employed to compare the differences in global metrics,Hub nodes,and modularity between DLBCL patients and healthy controls.Results Within the sparsity range of 0.1 to 0.5,DLBCL patients exhibited significant differences in the number and distribution of Hub nodes compared to healthy controls(P<0.05),while maintaining small-world properties(Sigma>1.1).Regarding modularity,alterations in node module assignments were noted in the metabolic brain networks of DLBCL patients at baseline,and the modular structure underwent significant reorganization following chemotherapy.Nevertheless,no significant difference in modularity(Q value)was found when compared to the control group(P>0.05).Conclusion The disease,coupled with R-CHOP chemotherapy regimen,disrupts Hub nodes and modularity of metabolic brain network in DLBCL patients,affecting brain function.关键词
弥漫大B细胞淋巴瘤/正电子发射断层/代谢脑网络/模块化Key words
diffuse large B-cell lymphoma/positron emission tomography/metabolic network/modularity引用本文复制引用
杨帆,肖静可,彭岱云,付静瑜,柳江燕..弥漫大B细胞淋巴瘤患者化疗前后PET代谢脑网络的Hub节点和模块化的差异[J].分子影像学杂志,2025,48(4):397-404,8.基金项目
甘肃省科技厅联合基金项目(24JRRA922) （24JRRA922）
兰州大学第二医院萃英科技创新计划应用基础研究(CY2023-MS-B10) （CY2023-MS-B10）
