分子影像学杂志2025，Vol.48Issue(4)：412-418,7.DOI:10.12122/j.issn.1674-4500.2025.04.03
颅内动脉瘤破裂风险因素预测:基于CT血管成像形态学联合临床因子和血液炎症指标
Risk factor prediction of intracranial aneurysm rupture:a multimodal analysis integrating CTA-derived morphology,clinical characteristics and hematological inflammatory markers
摘要
Abstract
Objective To analyze the risk factors for intracranial aneurysm(IA)rupture based on morphological parameters from computed tomography angiography(CTA),clinical characteristics of patients,and hematological inflammatory indicators.Methods A retrospective analysis was conducted on 176 IA patients treated at the Second Affiliated Hospital of Bengbu Medical University from November 2022 to September 2024.Based on the presence or absence of subarachnoid hemorrhage,patients were categorized into an unruptured group(n=72)and a ruptured group(n=104).Clinical data,hematological inflammatory indicators,and CTA-derived aneurysmal morphological parameters were compared between the two groups.Univariate and multivariate logistic regression analyses were employed to identify risk factors for IA rupture.Additionally,ROC curves and area under the curve(AUC)analyses were performed to evaluate the diagnostic efficacy of these risk factors.Results Irregular morphology(OR=3.079,95%CI:1.030-9.200,P=0.044),presence of daughter sacs(OR=3.271,95%CI:1.109-9.650,P=0.032),elevated size ratio(OR=2.117,95%CI:1.074-4.170,P=0.030),increased aspect ratio(OR=7.189,95%CI:1.242-41.619,P=0.028),and elevated systemic inflammatory response index(OR=1.500,95%CI:1.242-1.810,P<0.001)were identified as independent risk factors for IA rupture,with AUC values of 0.77,0.75,0.67,0.75 and 0.93,respectively.Conclusion Analysis based on CTA morphological parameters combined with clinical factors and blood inflammation indicators reveals that IAs with irregular morphology,presence of daughter sacs,high size ratio,high aspect ratio,and elevated systemic inflammatory response index are all high-risk factors for aneurysm rupture.These factors hold immense importance in accurately predicting the risk of aneurysm rupture.关键词
颅内动脉瘤/CT血管成像/动脉瘤破裂/蛛网膜下腔出血/危险因素Key words
intracranial aneurysm/computed tomography angiography/rupture of aneurysm/subarachnoid hemorrhage/risk factors引用本文复制引用
王玙璠,李裕国,顾长青,时凡,仝贺,李松,马宜传..颅内动脉瘤破裂风险因素预测:基于CT血管成像形态学联合临床因子和血液炎症指标[J].分子影像学杂志,2025,48(4):412-418,7.基金项目
安徽省临床医学研究转化专项项目(202304295107020072) （202304295107020072）
