分子影像学杂志2025，Vol.48Issue(4)：446-452,7.DOI:10.12122/j.issn.1674-4500.2025.04.09
18F-FDG PET/CT对CA125水平升高的卵巢癌术后腹膜转移患者的诊断价值
Diagnostic value of 18 F-FDG PET/CT based on elevated CA125 levels for peritoneal metastasis after ovarian cancer surgery
摘要
Abstract
Objective To compare the diagnostic value of 18F-FDG PET/CT versus conventional imaging methods in patients with postoperative peritoneal metastasis of ovarian cancer based on elevated CA125 levels.Methods This study retrospectively analyzed 87 postoperative patients diagnosed with ovarian cancer at the Affiliated Hospital of Xinjiang Medical University from January 2022 to December 2023.The diagnostic performance of four imaging modalities were investigated:18F-FDG PET/CT,transabdominal ultrasound(TAUS),transvaginal ultrasound(TVUS),contrast-enhanced computed tomography(CECT)or MRI,in detecting peritoneal metastasis in patients with elevated postoperative CA125 levels exceeding 35 U/mL.The parameters compared include sensitivity,specificity,accuracy,positive predictive value,and negative predictive value for each diagnostic method in the context of postoperative peritoneal metastasis in ovarian cancer patients.Results The sensitivities of 18F-FDG PET/CT,TAUS,TVUS,CECT or MRI for diagnosing postoperative peritoneal metastasis in ovarian cancer patients were 96.67%,37.70%,56.67%,79.37%,respectively;specificities were 85.19%,88.46%,92.59%,54.17%,respectively;accuracies were 93.10%,52.87%,67.82%,72.41%,respectively;positive predictive values were 93.54%,88.46%,94.44%,81.97%,respectively;negative predictive values were 92.00%,37.70%,49.02%,50.00%,respectively.Conclusion The accuracy of 18F-FDG PET/CT in diagnosing peritoneal metastasis or recurrence in patients with elevated CA125 levels following ovarian cancer surgery is high,enabling the early detection of peritoneal metastatic lesions.关键词
18F-FDG PET/CT/常规影像方法/CA125/卵巢癌/腹膜转移Key words
18F-FDG PET/CT/conventional imaging methods/CA125/ovarian cancer/peritoneal metastasis引用本文复制引用
苗春燕,刘大湃,高富,俞承成,曼菲达·买买提,蒲武涛,夏露花..18F-FDG PET/CT对CA125水平升高的卵巢癌术后腹膜转移患者的诊断价值[J].分子影像学杂志,2025,48(4):446-452,7.基金项目
新疆医科大学大学生创新训练项目(S202310760058) （S202310760058）
教育部产学合作协同育人项目(230805236315631) （230805236315631）
