斑马鱼模型在甲状腺癌研究中的优势、进展与前景OA

Thyroid cancer(TC)is a common endocrine malignancy with a complex pathogenesis difficult to replicate in vitro models.In recent years,the zebrafish model has emerged as a powerful tool in cancer research,due to its unique advantages such as small size,transparent embryos and larvae,and short growth cycle.Its application in tumor research has become increasingly widespread.In the study of TC,researchers have found that zebrafish can effectively simulate the occurrence and development of human TC,thereby providing a strong basis for investigating the molecular mechanisms of TC and identifying new therapeutic targets.This article briefly reviews the development of zebrafish model in clinical research and their advantages in cancer research,with a focus on the results obtained from the use of zebrafish model in TC studies,and discuss the future direction of zebrafish research in the field of TC.