超声心动图评估系统性红斑狼疮患者左心室功能损伤的研究进展OA

Systemic lupus erythematosus(SLE)is a kind of connective tissue disease characterized by the deposition of immune complexes,usually accompanied by cardiac damage.The main parameters of conventional echocardiography,such as left ventricular ejection fraction(LVEF),have insufficient sensitivity in diagnosis of subclinical left ventricular dysfunctions.It is challenging to identify cardiac dysfunctions in SLE patients with a condition of preserved LVEF at an early stage.Nowadays,the extensive application of various echocardiography technology such as speckle tracking imaging,real-time three-dimensional echocardiography and myocardial work can evaluate the changes of left ventricular function in SLE patients more comprehensively and more systematically,providing the basis for early clinical identification of left ventricular involvement in SLE patients.This article reviews the progress of cardiac damage pathogenesis and echocardiography in evaluating the changes of left ventricular structure and function in SLE patients.