广州医药2025，Vol.56Issue(4)：509-515,7.DOI:10.20223/j.cnki.1000-8535.2025.04.011
复方黄芪颗粒对小鼠抗疲劳的作用及其机制研究
Study on the anti-fatigue effect of compound Huangqi granules on mice and its mechanism
摘要
Abstract
Objective To investigate the anti-fatigue effects of compound Huangqi granules(CHG)and its mechanism.Methods Forty-eight male BALB/C mice were randomly divided into blank control group,9.1,18.2,27.3 g/kg CHG group(test groups).The test groups received different concentrations of CHG solution by gavage,and the blank control group mice were given equal volume saline.After 30 days of administration,the mice were tested,meanwhile the anti-fatigue effect and mechanism were investigated.Results Compared with blank control group,there was no significant difference in body weight(P＞0.05).The exhaustive swimming time and rod turning endurance time of mice were significantly prolonged(P＜0.01).The serum levels of blood urea nitrogen,lactate dehydrogenase and malondialdehyde were significantly decreased(P＜0.01),while the liver and muscle glycogen levels(P＜0.05)and superoxide dismutase activity were increased(P＜0.01).In vitro antioxidant tests showed that CHG can remove(1,1-Diphenyl-2-picrylhydrazyl,ABTS)and(2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid,DPPH)free radicals in a dose-dependent manner.When the CHG concentration is 100 mg/mL,the DPPH free radical scavenging ability of CHG can reach 85.030 3%.When the CHG concentration was 25 mg/mL,the scavenging ability of CHG to ABTS free radicals reached 96.357 2%.Conclusions CHG has anti-fatigue effect,and its mechanism may be related to anti-oxidation effect.关键词
复方黄芪颗粒/抗疲劳/抗氧化/机制Key words
compound Huangqi granules/anti-fatigue/anti-oxidation/mechanism引用本文复制引用
张志强,张鹏,王松萍,刘江,王晓聪..复方黄芪颗粒对小鼠抗疲劳的作用及其机制研究[J].广州医药,2025,56(4):509-515,7.基金项目
广东省医院协会医院药学科研专项基金项目(YXKY202215) （YXKY202215）
广东省医院药学研究基金项目(2021A16) （2021A16）
深圳市医疗卫生三名工程项目(NO:SZSM202301035) （NO:SZSM202301035）
