广州医药2025，Vol.56Issue(4)：516-522,7.DOI:10.20223/j.cnki.1000-8535.2025.04.012
早产儿呼吸窘迫综合征拔管后NIPPV和NCPAP作为无创呼吸支持过渡的临床效果对比
Comparison of the clinical effects of NIPPV and NCPAP as a noninvasive respiratory support for preterm infants after extubation
摘要
Abstract
Objective To explore the difference of clinical effect of nasal intermittent positive pressure ventilation(NIPPV)and nasal continuous positive pressure ventilation(NCPAP)as non-invasive respiratory support mode after extubation in preterm infants with endotracheal intubation.Methods Sixty-six cases of preterm infants with neonatal respiratory distress syndrome treated in our hospital from January 2021 to June 2023 were included.All the subjects were randomly divided into NIPPV group(n=33)and NCPAP group(n=33).The blood gas analysis results,weaning failure rate,non-invasive respiratory support time,oxygen inhalation time after noninvasive ventilation,total oxygen administration time.were compared between the two groups.Results After 12 hours of noninvasive respiratory support,PaO2 in the NIPPV group increased to(76.46±1.10)mmHg,which was significantly higher than that(75.51±2.15)mmHg in the NCPAP group(t=2.249,P=0.028).In addition,SaO2 in the NIPPV group increased to(96.36±0.52)%,which was also significantly higher than that(96.07±0.59)%in the NCPAP group(t=2.138,P=0.034).The PaCO2 in the NIPPV group decreased to(41.39±0.74)mmHg,which was lower than that(41.87±0.95)mmHg in the NCPAP group(t=-2.230,P=0.025).The duration of non-invasive respiratory support in the NIPPV group(3.09±0.52)days was shorter than that(3.45±0.62)days in the NCPAP group,and the difference was statistically significant(t=2.584,P=0.012).Similarly,the total duration of oxygen administration in the NIPPV group(9.52±0.76)days was shorter than that(10.00±0.79)days in the NCPAP group,and the difference was statistically significant(t=-2.548,P=0.013).There were no significant differences in weaning failure rate,oxygen inhalation time after noninvasive respiratory support,and incidence of adverse reactions between the two groups(P＞0.05).Conclusions Compared with NCPAP mode,NIPPV mode for non-invasive respiratory support in preterm infants after extubating has better clinical effect,and it is worthy of clinical application.关键词
早产儿/经鼻间歇正压通气/经鼻持续正压通气/临床效果Key words
preterm infants/NIPPV/NCPAP/clinical effect引用本文复制引用
吴国豪,吴贞德,陈栋才,康健泉,林家叶..早产儿呼吸窘迫综合征拔管后NIPPV和NCPAP作为无创呼吸支持过渡的临床效果对比[J].广州医药,2025,56(4):516-522,7.基金项目
湛江市科技计划项目(2021B01020) （2021B01020）
