摘要
Abstract
Objective This study aims to compare ultrasound-guided versus conventional catheterization via peripheral venous(PV)cath-eterization,central venous catheterization(CVC),and peripheral artery(PA)catheterization access for the collection of chimeric antigen receptor T cells(CAR-T).Methods We retrospectively analyzed 248 CAR-T cell collection procedures performed in our department between January 1,2019,and July 31,2024.Patients were allocated to two groups based on whether ultrasound guidance was used for catheter placement:the ultrasound-guided group and the conventional group.Within each group,we further subdivided by access route-PV,CVC,or PA.We compared puncture pain scores,number of puncture attempts,puncture time,direct medical costs,and total collection time across the different access routes and guidance methods.Results The CVC subgroup experienced significantly higher puncture pain scores and longer puncture times than both the PV and PA subgroups(P<0.05),with no significant difference between PV and PA(P>0.05).Direct medical costs were highest in the CVC subgroup compared to PV and PA,with significant differences(P<0.05).The PA subgroup achieved significantly shorter total collection times than both the PV and CVC subgroups(P<0.05).In the ultrasound-guided group,the PV subgroup required significantly fewer puncture attempts than the conventional PV subgroup(P<0.05),and the ultrasound-guided CVC subgroup also required fewer attempts than its conventional counterpart(P<0.05).Con-clusion Ultrasound guidance during vessel access for CAR-T cell collection reduces the number of puncture attempts in PV catheteriza-tion.Among the three access routes,PV and PA catheterization offer advantages over CVC in terms of lower pain,shorter puncture and collection times,and reduced costs.PA catheterization access,with its higher arterial flow and pressure,further enhances collection efficiency and is particularly suitable for patients with poor venous access.关键词
外周静脉/中心静脉/外周动脉/CAR-T细胞采集/血管通路/护理Key words
Peripheral vein/Central vein/Peripheral artery/CAR-T cell collection/Vascular access/Nursing分类
医药卫生
