西部中医药2025，Vol.38Issue(4)：1-5,5.DOI:10.12174/j.issn.2096-9600.2025.04.01
应用Box-Behnken设计-响应面法优化复方白鲜皮软膏剂的成型工艺
Optimization of the Molding Process of Compound Baixianpi Ointment Using the Box-Behnken Design-response Surface Methodology
摘要
Abstract
Objective:To optimize the molding process for the ointment of compound Baixianpi(dictamni cortex)eczema formula.Methods:The uniformity,stability,and spreadability of ointment were used as evaluation indicators to conduct the comprehensive scoring in the pre-experiment,and the best matrix type was selected from the oil-based,water-soluble and emulsion(W/O type and O/W type)matrix;Single factor experiment and Box-Behnken design-response surface methodology were used to optimize the preparation process,including the amount of oil phase and water phase,and then to determine the best matrix prescription.Results:The Box-Behnken design-response surface model P<0.000 1,and P>0.05 for the test of lack-of-fit,indicating high significance and good fit;The analysis using Design-Expert software revealed that the optimal parameters of the preparation process were:petrolatum 1.600 g,lanolin 1.102 g,liquid paraffin 1.799 g and glycerin 3.600 g,based on actual preparation conditions,1.60 g of petrolatum,1.10 g of lanolin,1.79 g of liquid paraffin,and 3.60 g of glycerin were selected;the average OD value from the process validation trials was 8.66,with a small deviation from the predicted value,the comprehensive scores for all three batches of samples were greater than 25,indicating good stability,spreadability,and uniformity of the ointment.Conclusion:The molding process of compound Baixianpi ointment,optimized by Box-Behnken design-response surface methodology,is stable and feasible.关键词
复方白鲜皮软膏剂/基质/Box-Behnken设计-响应面法/成型工艺Key words
compound Baixianpi ointment/matrix/Box-Behnken design-response surface methodology/the molding process分类
医药卫生引用本文复制引用
杨娟,甄世福,袁文珺,柴露露,陈娟江,魏其云..应用Box-Behnken设计-响应面法优化复方白鲜皮软膏剂的成型工艺[J].西部中医药,2025,38(4):1-5,5.基金项目
兰州市卫生健康科技发展项目(2019-025). （2019-025）
