国际神经病学神经外科学杂志2025，Vol.52Issue(2)：8-22,15.DOI:10.16636/j.cnki.jinn.1673-2642.2025.02.002
进行性假肥大性肌营养不良的糖皮质激素治疗循证指南(2025版)
Evidence-based guidelines for the use of glucocorticoids in Duchenne muscular dystrophy(2025)
摘要
Abstract
Duchenne Muscular Dystrophy(DMD)is the most common form of muscular dystrophy in children,with a poor prognosis,and most patients die from respiratory or heart failure around the age of 30.Glucocorticoids(GC)are often used to slow down the decline of muscle strength and function in DMD patients.However,the long-term use of GC inevitably leads to some side effects,and the use of GC is still not standardized in China.To guide pediatricians and neurologists in standardizing the use of GC in DMD patients,the guidelines are developed based on existing evidence-based medicine,with the application of Grading of Recommendations Assessment,Development and Evaluation.To address clinical issues such as the timing,dosage regimens,efficacy evaluation,monitoring and management of side effects,course,and transition to adult care of GC treatment in DMD,30 recommendations are formulated to provide guidance and a decision-making basis for healthcare workers in GC treatment and follow-up management of DMD patients.关键词
进行性假肥大性肌营养不良/糖皮质激素/儿童/循证指南Key words
Duchenne muscular dystrophy/glucocorticoid/child/evidence-based guideline分类
临床医学引用本文复制引用
四川大学华西第二医院,四川大学华西医院,罗蓉,肖波..进行性假肥大性肌营养不良的糖皮质激素治疗循证指南(2025版)[J].国际神经病学神经外科学杂志,2025,52(2):8-22,15.基金项目
国家重点研发计划(2021YFC1005305) （2021YFC1005305）
四川省科技厅区域创新合作项目(2020YFQ0021). （2020YFQ0021）
