工业微生物2025，Vol.55Issue(2)：211-214,4.DOI:10.3969/j.issn.1001-6678.2025.02.059
光甘草定通过激活Nrf2/HO-1通路,减轻碘酸钠诱导的ARPE-19细胞损伤
Glabridin Alleviates Sodium Iodate-induced ARPE-19 Damage by Activating the Nrf2/HO-1 Signaling Pathway
摘要
Abstract
The paper investigated the protective effect of glabridin on ARPE-19 cells induced by sodium iodate(NaIO3).MTT assay was used to detect the cell viability and cytotoxicity of ARPE-19 cells.Flow cytometry was used to detect the reactive oxygen species(ROS)level.Western Blot was used to detect the expression of Nrf2 and HO-1 proteins.As a result,glabridin can significantly inhibit the ROS production induced by NaIO3 and reduce the apoptosis of ARPE-19.The potential mechanism was mainly that the increse of the expression of Nrf2 and HO-1 proteins protected RPE from ROS production and apoptosis induced by NaIO3.Glabridin can reduce the apoptosis of ARPE-19 cells,which may be related to the Nrf2/HO-1 signaling pathway.关键词
黄斑变性/光甘草定/氧化应激/眼底病Key words
macular degeneration/glabridin/oxidative stress/fundus disease引用本文复制引用
苗琪,魏达亨..光甘草定通过激活Nrf2/HO-1通路,减轻碘酸钠诱导的ARPE-19细胞损伤[J].工业微生物,2025,55(2):211-214,4.基金项目
辽宁省教育厅科研平台建设项目(编号:LJ232410160047) （编号:LJ232410160047）
辽宁省教育厅高等学校基本科研项目(编号:LJKFZ20220248). （编号:LJKFZ20220248）
