西部中医药2025，Vol.38Issue(4)：41-46,6.DOI:10.12174/j.issn.2096-9600.2025.04.09
基于数据挖掘的银屑病伴焦虑抑郁状态的用药规律探究
Data Mining-based Discussion on the Medication Rules of Psoriasis with Anxiety and Depression
摘要
Abstract
Objective:To explore the medication rules of traditional Chinese medicine in the treatment of psoriasis with anxiety and depression using data mining technology,so as to provider certain reference for clinical therapy of the disease.Methods:CNKI,Wanfang and VIP were chosen as the source of the data,Excel 2019,SPSS Modeler 18.0 and SPSS Statistics 20.0 and other softwares were applied to perform frequency statistics,association rule analysis and system clustering analysis of herbal compounds that met the inclusion criteria.Results:Sixty prescriptions were included,containing 120 herbs,mostly of cold,warm and neutral nature,with the flavors of mainly bitter,sweet and pungent,and most entering the meridians of liver and lung.The top ten high-frequency herbs were Dihuang(Rehmanniae radix),Chaihu(Bupleuri Radix),and Gancao(Glycyrrhizae radix et rhizoma),Danggui(Angelicae sinensis radix),Mudanpi(Moutan cortex),Tufuling(Smilacis glabrae rhizoma),Zicao(Arnebiae radix),Baishao(Paeoniae radix alba),Baixianpi(Dictamni cortex),and Huangqin(Scutellariae radix),and they were the ones of clearing heat and tonifying;the analysis of association rules displayed that the common combinations were Dihuang-Dangshen(Codonopsis radix),Chaihu-Zhizi(Gardeniae fructus),Chaihu-Yujin(Curcumae radix),Dihuang-Mudanpi-Chaihu,Chaihu-Dangshen-Dihuang,and Huangqin-Zhizi-Chaihu;cluster analysis displayed that the drugs for treating psoriasis from blood were divided into three categories and the results had good clustering effects.Conclusion:The treatment for psoriasis with anxiety and depression mainly adopts clearing heat and cooling blood,soothing liver for relieving Qi stagnation,nourishing blood and detoxification as the therapeutic methods,and the study has primarily surveyed the medication rules of the treatment,which could provide certain reference for clinical application of herbs and research&development of new prescriptions.关键词
银屑病/焦虑抑郁状态/数据挖掘/关联分析/用药规律Key words
psoriasis/anxiety and depression/data mining/association rules/medication rules分类
医药卫生引用本文复制引用
仪凡,王晓旭,赵子慧,金琦,张广中..基于数据挖掘的银屑病伴焦虑抑郁状态的用药规律探究[J].西部中医药,2025,38(4):41-46,6.基金项目
国家自然科学基金(81974572,82274523). （81974572,82274523）
