国际神经病学神经外科学杂志2025，Vol.52Issue(2)：40-45,6.DOI:10.16636/j.cnki.jinn.1673-2642.2025.02.006
轻度颅脑损伤患者GCS及血清GFAP、UCH-L1、IL-6与早期CT阴性表现的相关性
Correlation of Glasgow Coma Scale score and the serum levels of glial fibrillary acidic protein,ubiquitin carboxy-terminal hydrolase L1,and interleukin-6 with early negative computed tomography findings in patients with mild craniocerebral injury
摘要
Abstract
Objective To investigate the correlation of Glasgow coma scale(GCS)score and the serum levels of glial fibrillary acidic protein(GFAP),ubiquitin carboxy-terminal hydrolase L1(UCH-L1),and interleukin-6(IL-6)with early negative computed tomography(CT)findings in patients with mild craniocerebral injury.Methods A total of 52 patients with mild craniocerebral injury who were treated and had negative CT findings in The Third People's Hospital of Bengbu Affiliated to Bengbu Medical University from January 2019 to May 2023 were enrolled as negative group,and 58 patients with mild craniocerebral injury who had positive CT findings were enrolled as positive group.The two groups were compared in terms of GCS score,GFAP,UCH-L1,and IL-6.A logistic regression analysis was used to identify the influencing factors for early negative CT findings in patients with mild craniocerebral injury,and the Pearson correlation analysis was used to explore the correlation of GCS score,GFAP,UCH-L1,and IL-6 with early negative CT findings.MedCalc software was used to plot the receiver operating characteristic(ROC)curve of GCS score,GFAP,UCH-L1,and IL-6 for the diagnosis of early negative CT findings in patients with mild craniocerebral injury.Results GCS score,positive nervous system findings,and relatively low levels of GFAP,UCH-L1,and IL-6 were risk factors for early negative CT findings in patients with mild craniocerebral injury(P<0.05).GCS score was positively correlated with early negative CT findings in patients with mild craniocerebral injury(P<0.001),and GFAP,UCH-L1,and IL-6 were negatively correlated with early negative CT findings in patients with mild craniocerebral injury(P<0.001).GCS score combined with GFAP,UCH-L1,and IL-6 had an area under the ROC curve of 0.970 in the diagnosis of early negative CT findings in patients with mild craniocerebral injury.Conclusions GCS score,GFAP,UCH-L1,and IL-6 can be used for the diagnosis of early negative CT findings in patients with mild craniocerebral injury,and combined measurement of the four indicators can improve diagnostic accuracy.关键词
轻度颅脑损伤/格拉斯哥昏迷量表/神经胶质纤维酸性蛋白/泛素羧基端水解酶/白细胞介素6/电子计算机断层扫描Key words
mild craniocerebral injury/Glasgow coma scale/glial fibrillary acidic protein/ubiquitin carboxy-terminal hydrolase L1/interleukin-6/computed tomography分类
临床医学引用本文复制引用
尹明东,郭传军,吕晨..轻度颅脑损伤患者GCS及血清GFAP、UCH-L1、IL-6与早期CT阴性表现的相关性[J].国际神经病学神经外科学杂志,2025,52(2):40-45,6.基金项目
安徽省卫生健康委科研项目(AHWJ2021b139) （AHWJ2021b139）
蚌埠医学院自然科学重点项目(BYKY2019277ZD). （BYKY2019277ZD）
