国际神经病学神经外科学杂志2025，Vol.52Issue(2)：62-67,6.DOI:10.16636/j.cnki.jinn.1673-2642.2025.02.010
血清γ-谷氨酰转移酶联合同型半胱氨酸预测急性脑梗死患者卒中后认知障碍的效能
Efficacy of serum gamma-glutamyl transferase combined with homocysteine in predicting post-stroke cognitive impairment in patients with acute cerebral infarction
熊兵 1杨娇 1唐善鹏 1王康 1王琼芝1
作者信息
- 1. 洪湖市人民医院神经内科,湖北 洪湖 433200
- 折叠
摘要
Abstract
Objective To investigate the efficacy of serum gamma-glutamyl transferase(GGT)combined with homocysteine(Hcy)in predicting post-stroke cognitive impairment(PSCI)in patients with acute cerebral infarction(ACI).Methods A total of 100 ACI patients who were admitted to Department of Neurology,Honghu People's Hospital,from May 2021 to May 2022 were enrolled as ACI group,and 50 individuals who underwent physical examination were enrolled as control group.According to the presence or absence of PSCI,the patients with ACI were divided into PSCI group and non-PSCI group.The above groups were compared in terms of clinical data,Montreal Cognitive Assessment(MoCA)score,serum lipid parameters,and the levels of GGT and Hcy.A multivariate logistic regression analysis was used to determine the risk factors for PSCI in ACI patients,and the receiver operating characteristic(ROC)curve was used to analyze their efficacy in predicting PSCI.Results Among the 100 ACI patients,73(73.0%)developed PSCI.The ACI group showed no significant change in MoCA score from the acute stage to 6 months after cerebral infarction(P>0.05),while the non-PSCI group had a significant increase in MoCA score from the acute stage to 6 months after cerebral infarction(P<0.05).The ACI group had significantly higher levels of GGT and Hcy than the control group(P<0.05),and compared with the non-PSCI group,the PSCI group had significantly higher levels of TG,GGT,and Hcy and a significantly lower level of HDL-C(P<0.05).The mild ACI group had significantly lower levels of GGT and Hcy than the moderate and severe ACI groups,and the moderate group had significantly lower levels than the severe group(P<0.05).The multivariate logistic regression analysis showed that serum GGT and Hcy were risk factors for PSCI in ACI patients(P<0.05).GGT+Hcy had a sensitivity of 98.63%and a negative predictive value of 95.24%in predicting PSCI,which were significantly higher than those of each indicator alone.Conclusions There are abnormal increases in the serum levels of GGT and Hcy in ACI patients,and the combination of GGT and Hcy has a good value in predicting PSCI.关键词
急性脑梗死/γ-谷氨酰转移酶/同型半胱氨酸/卒中后认知障碍Key words
acute cerebral infarction/gamma-glutamyl transferase/homocysteine/post-stroke cognitive impairment分类
临床医学引用本文复制引用
熊兵,杨娇,唐善鹏,王康,王琼芝..血清γ-谷氨酰转移酶联合同型半胱氨酸预测急性脑梗死患者卒中后认知障碍的效能[J].国际神经病学神经外科学杂志,2025,52(2):62-67,6.
