化工学报2025，Vol.76Issue(4)：1702-1710,9.DOI:10.11949/0438-1157.20240965
叶酸修饰的pH响应共聚物混合胶束用于抗癌药物递送
Folate-modified pH-responsive copolymer mixed micelles for anticancer drug delivery
摘要
Abstract
Folate-modified pH-sensitive copolymer P1(FA-PEG-PHEMA-PDEAEMA)was prepared by end-bromination,esterification,and atom transfer radical polymerization(ARGET ATRP)reaction.Copolymer P2(PCL-PHEMA-PEGMA)was synthesized by ring-opening,bromination,and ATRP reactions.The structure,molecular weight,and molecular weight distribution of the copolymers were tested by 1H NMR,FTIR,and GPC.The CMC values of copolymers P1,P2,and mixed copolymer P1/P2 were 5.02,1.58 and 2.51 mg/L,respectively,indicating that the copolymers could form stable micelles in solution.The drug-loaded micelles were prepared by dialysis method,and the morphology was spherical.The comprehensive drug loading performance and drug controlled release performance of mixed copolymer micelles MM were better than those of single copolymer micelles.Folate-modified drug-loaded micelles exhibited better inhibitory effects on HepG2 cells.关键词
共聚物/混合胶束/药物递送/合成Key words
copolymer/mixed micelles/drug delivery/synthesis分类
化学工程引用本文复制引用
赵海钎,陈方,陈涛,郭建维,林文静,杨楚芬..叶酸修饰的pH响应共聚物混合胶束用于抗癌药物递送[J].化工学报,2025,76(4):1702-1710,9.基金项目
国家自然科学基金项目(21676058) （21676058）
广东省自然科学基金项目(2024A1515011182) （2024A1515011182）
广州市科技计划项目(2023A04J0064) （2023A04J0064）
