河南中医2025，Vol.45Issue(5)：778-787,10.DOI:10.16367/j.issn.1003-5028.2025.05.0127
糖基化终产物在糖尿病肾病中的作用概述
Overview of the Role of Advanced Glycation End Products in Diabetic Kidney Disease
摘要
Abstract
Diabetic kidney disease(DKD)is a common microvascular complication in diabetic patients,and advanced glycation end products(AGEs)play a critical role in its pathogenesis.AGEs induce renal injury through multiple pathways,including direct damage,binding to the RAGE receptor,promoting inflammatory responses and oxidative stress,and accelerating fibrosis and podocyte injury.AGEs detection holds promise as an early diagnostic biomarker for DKD.Current therapeutic strategies targeting AGEs primarily focus on inhibiting their formation and antagonizing AGEs receptors,including agents such as aminoguanidine,plant-derived compounds,ACE inhibitors,soluble RAGE(sRAGE),and anti-RAGE antibodies,etc.Additionally,interventions such as antioxidants,dietary modifica-tions,and lifestyle adjustments may help mitigate the adverse effects of AGEs.Although drugs targeting AGEs have shown promising re-sults in animal experiments,their efficacy in clinical trials remains unsatisfactory.Therefore,further research into the mechanisms of AGEs is needed to accelerate the development of clinical therapies.Moreover,TCM lacks a standardized syndrome differentiation classi-fication system,and treatment approaches vary significantly among individuals.It is essential to establish a universally recognized TCM diagnostic framework based on its theoretical system of principles,methods,formulas,and herbs,while strengthening research on individ-ualized differences and standardized efficacy criteria.Furthermore,relying solely on pharmacological interventions may not fully address the complexity of AGEs-related diseases;integrating lifestyle interventions could enhance therapeutic outcomes.Future research should focus on the clinical application of AGEs and their feasibility as potential therapeutic targets to develop more precise treatment strate-gies.关键词
糖基化终产物/糖尿病肾病/肾脏损伤/炎症反应/氧化应激Key words
advanced glycation end products(AGEs)/diabetic kidney disease(DKD)/renal injury/inflammatory response/oxidative stress分类
中医学引用本文复制引用
陆依萍,马迪,段凤梅,段秋言,陈龙满,王霞..糖基化终产物在糖尿病肾病中的作用概述[J].河南中医,2025,45(5):778-787,10.基金项目
云南省高层次中医药学科带头人培养项目(第二批)[云财社(2024)103号] （第二批）
北京医学奖励基金会课题项目(YXJL-2024-1324-0384) （YXJL-2024-1324-0384）
