河南中医2025，Vol.45Issue(5)：788-795,8.DOI:10.16367/j.issn.1003-5028.2025.05.0128
基于血管再生机制探讨中西医治疗膝骨关节炎
Exploring the Mechanisms of Angiogenesis in Integrated Traditional Chinese and Western Medicine Treatment for Knee Osteoarthritis
摘要
Abstract
Knee osteoarthritis(KOA)is a common joint disease characterized by degenerative changes in articular cartilage and osteo-phyte formation at joint margins.During arthritis progression,abnormal angiogenesis is activated,leading to vascular hyperplasia in the subchondral bone and intra-cartilage regions.This exacerbates inflammatory responses and cartilage degradation,accelerating KOA pro-gression.Current research focuses on inhibiting intra-cartilage angiogenesis based on angiogenesis mechanisms.Blocking abnormal an-giogenesis may protect joint stability,reduce pro-inflammatory mediator release,degrade catabolic enzymes,regulate growth factor pro-duction,delay cartilage destruction,preserve the self-repair environment,alleviate synovitis,and mitigate pain.However,challenges in present research still remain as follows:(1)Mechanism Complexity:The specific interactions between angiogenesis and KOA are un-clear.Factors such as angiogenesis,increased vascular permeability,and perivascular inflammation complicate targeted interventions.(2)Lack of Specific Biomarkers:Highly sensitive and specific biomarkers to assess angiogenesis activity and KOA progression are lac-king,hindering personalized treatment strategies.(3)Adverse Reactions of Therapeutic Approaches:Angiogenesis-inhibiting drugs may cause systemic side effects,such as impairing normal tissue vascularization,delaying wound healing,or damaging organ function,etc.(4)Long-Term Efficacy and Safety:Despite positive short-term clinical outcomes,long-term safety and efficacy require further valida-tion,including risks of drug resistance or disease relapse,etc.(5)Standardization of Integrated Therapies:While integrated traditional Chinese and Western medicine shows potential,inconsistent standards and prescription variability limit treatment consistency and repro-ducibility.Therefore,future research should conduct in-depth research on the interaction mechanisms between angiogenesis and KOA,i-dentify and validate specific angiogenesis-related biomarkers,establish standardized guidelines for integrated therapies,and carry out multicenter trials to validate their efficacy and safety.关键词
膝骨关节炎/血管再生/软骨破坏/软骨退化/滑膜炎/关节疼痛/中西医结合疗法Key words
knee osteoarthritis(KOA)/angiogenesis/cartilage destractior/cartilage degenaration/synovitis/joint pain/integrated tradi-tional Chinese and Western medicine therapy分类
中医学引用本文复制引用
LE Thi Quynh,蔡永刚,任花梅,李玮琦,周友龙..基于血管再生机制探讨中西医治疗膝骨关节炎[J].河南中医,2025,45(5):788-795,8.基金项目
河南省特色骨干学科中医学学科建设项目(STG-ZYX02-202115,STG-ZYXKY-2020032) （STG-ZYX02-202115,STG-ZYXKY-2020032）
河南省重点科学基金项目(232300421128) （232300421128）
