青鳉elavl2基因的表达分析OA北大核心

Loss of gsdf in the medaka leads to excessive proliferation of germ cells and XY male germ cell sex reversal to oocytes.Transcriptomic analysis revealed a significant upregulation of the elavl2 gene expression in both XX and XY gsdf-deficient gonads,suggesting a putative inhibition of sex gland elavl2 expression by Gsdf signaling.Elavl2 had a high evolutionary conservation among species.ELAVL2 was expressed in various tissues after embryonic development and sexual maturation,with notably high expression in the gonads and brain,indicated its critical role in gametogenesis and brain function.Chemical in situ hybridization demonstrates predominant expression of elavl2 in primary spermatogonia and oocytes within normal testes and ovaries.Consistent with the relative expression of qPCR in gonads,elavl2 may play an important role in gamete production.this work supports and provides comparative evolutionary insights into the regulatory mechanisms underline the vertebrate sex differentiation.