鸟类与爬行类FOXP2基因的分子进化OA北大核心

FOXP2 gene of Fox family widely exists in the animal kingdom and is an important gene related to sound.Its mutation can cause human language disorder.FOXP2 gene is closely related to the language ability and learning behavior of birds and reptiles.In order to understand its evolutionary history,66 species of birds and 30 species of reptiles were studied.Based on genomic data,the molecular evolution of FOXP2 gene in birds and reptiles was discussed by using selection pressure analysis and phylogenetic analysis.The results showed that:first,although both birds and reptiles had positive selection sites,FOXP2 gene was very conserved in reptiles and birds,and showed purifying selection on the whole;second,the FOXP2 gene of songbirds in birds did not undergo positive selection evolution,and there was no positive selection site,but the ω value was larger than that of other birds,indicating that the evolution rate of FOXP2 gene in songbirds is faster,which may be related to its outstanding singing ability;third,although FOXP2 of both birds and reptiles were under purifying selection,birds havd greater ω,indicating that birds were under relaxed selection and the FOXP2 gene of birds had a faster evolution rate than that of reptiles.The results of this study provide further theoretical basis for the study of the evolution and function of FOXP2 gene,and bring reference and enlightenment to the exploration of human language mechanism.