中医药导报2025，Vol.31Issue(4)：142-146,5.DOI:10.13862/j.cn43-1446/r.2025.04.024
青蒿素及其衍生物在神经退行性疾病中的应用研究进展
Research Progress on the Application of Artemisinin and Its Derivatives in Neurodegenerative Diseases
摘要
Abstract
With the intensification of global population aging,the social medical and economic burdens caused by neurodegenerative diseases are steadily increasing.Artemisinin and its derivatives have shown potential in the treatment of neurodegenerative diseases due to their anti-inflammatory,antioxidant,anti-tumor,immunomodulatory,and neuroprotective effects.This paper summarizes the potential applications of artemisinin and its derivatives in Alzheimer's disease,Parkinson's disease,amyotrophic lateral sclerosis,and Huntington's disease.It explores their neuroprotective effects through multiple mechanisms,such as regulating amyloid protein metabolism,anti-oxidative stress,anti-inflammation,and repairing neuronal damage.It also analyzes the challenges that their clinical applications still face,including low bioavailability and rapid metabolism.It is proposed that in the future,further research is needed on long-term safety and efficacy,and the development of new dosage forms and derivatives should be carried out to realize their potential.关键词
神经退行性疾病/青蒿素/青蒿素衍生物/阿尔茨海默病/帕金森病/神经保护/综述Key words
neurodegenerative diseases/artemisinin/artemisinin derivatives/Alzheimer's disease/Parkinson's disease/neuroprotection/review分类
中医学引用本文复制引用
刘瑶怡,邱浩文,马虹露,胡灵娟,刘奕,李国庆..青蒿素及其衍生物在神经退行性疾病中的应用研究进展[J].中医药导报,2025,31(4):142-146,5.基金项目
湖南省教育厅科学研究项目(21A0268) （21A0268）
湖南省研究生科研创新项目(LXBZZ2024238) （LXBZZ2024238）
湖南省自然科学基金项目(2024JJ6379,2025JJ50541) （2024JJ6379,2025JJ50541）
