中医药导报2025，Vol.31Issue(4)：157-160,225,5.DOI:10.13862/j.cn43-1446/r.2025.04.027
基于骨转移分析570例前列腺癌患者中医证素分布规律
Analysis of Traditional Chinese Medicine Syndrome Elements Distribution Pattern in 570 Prostate Cancer Patients Based on Bone Metastasis
摘要
Abstract
Objective:To explore the distribution pattern of traditional Chinese medicine(TCM)syndrome elements in prostate cancer based on bone metastasis,and provide reference for the syndrome research,diagnosis and treatment of prostate cancer.Methods:The clinical data of 570 prostate cancer patients were retrospectively collected and divided into 289 cases without bone metastasis group and 281 cases with bone metastasis group.The syndrome elements of disease location and disease nature of the two groups of patients were studied.Results:Among the 570 prostate cancer patients,429 cases had the syndrome element of disease location in the kidney,including 207 cases in the non-bone metastasis group and 222 cases in the bone metastasis group.189 cases had the disease location in the spleen,including 109 cases in the non-bone metastasis group and 80 cases in the bone metastasis group.118 cases had the disease location in the lung.The main pathognomonic elements were Qi deficiency,blood deficiency,Yang deficiency and blood stasis.There were more patients with yang deficiency in the group without bone metastasis than in the group with bone metastasis,and there were more patients with Qi deficiency,blood deficiency,blood stasis,dampness,Yin deficiency and phlegm in the group with bone metastasis than in the group without bone metastasis.The results of the two-item pathogenicity-pathogenicity association analysis showed that in terms of support degree,both the non-bone metastasis group and the bone metastasis group had the highest degree of support for Qi deficiency+kidney.In terms of confidence degree,the non-bone metastasis group had the highest degree of confidence for Yang deficiency+kidney,and the bone metastasis group had the highest degree of confidence for blood stasis+kidney.The results of the three-item association analysis showed that in terms of support degree,the support degree of Yang deficiency+Qi deficiency+kidney was the highest in the non-bone metastasis group,and the support degree of blood stasis+Qi deficiency+kidney was the highest in the bone metastasis group.In terms of confidence degree,the confidence degree of Yang deficiency+Qi deficiency+kidney was the highest in the non-bone metastasis group,and the confidence degree of blood stasis+Yang deficiency+kidney was the highest in the bone metastasis group.Conclusion:The core disease location of prostate cancer is in the kidney,and the main disease location also include the spleen and lung.The syndrome elements of disease location in patients without bone metastasis are mainly the kidney and the spleen,while those in patients with bone metastasis are mainly the kidney,the spleen,and the lung.Yang deficiency,Qi deficiency,blood deficiency,blood stasis,dampness,Yin deficiency,and phlegm were the main pathognomonic elements.The syndrome element of disease nature in patients without bone metastasis is mainly Yang deficiency,and the main syndrome elements of disease nature in patients with bone metastasis,in addition to blood stasis,also involve Qi deficiency,Yang deficiency,blood deficiency,Yin deficiency,dampness,and phlegm.Kidney deficiency and blood stasis are the core pathogenesis of prostate cancer.关键词
前列腺癌/骨转移/证素/肾虚/血瘀/回顾性研究Key words
prostate cancer/bone metastasis/syndrome elements/kidney deficiency/blood stasis/retro-spective study分类
医药卫生引用本文复制引用
刘长鑫,王浩瞩,张子淑,吴泳蓉,周青,田雪飞..基于骨转移分析570例前列腺癌患者中医证素分布规律[J].中医药导报,2025,31(4):157-160,225,5.基金项目
国家自然科学基金区域联合创新项目(U20A20408) （U20A20408）
国家自然科学基金项目(82074450,82104861) （82074450,82104861）
