保健医学研究与实践2025，Vol.22Issue(1)：74-80,7.DOI:10.11986/j.issn.1673-873X.2025.01.12
经皮肾镜碎石术后尿路感染危险因素分析及CRP/Alb比值的预测效能
Analysis of risk factors for urinary tract infection after percutaneous nephrolithotomy and predictive performance of the Creactive protein/albumin ratio
摘要
Abstract
Objective To analyze the risk factors for urinary tract infection(UTI)following percutaneous nephrolithotomy(PCNL)and to evaluate the predictive performance of the Creactive protein/albumin(CRP/Alb)ratio for postPCNL UTI.Methods A total of 114 patients with upper urinary tract stones who underwent PCNL at a hospital in Sichuan Province be-tween June 2021 and December 2023 were enrolled.Patients were assigned to a noninfection group(n=86)and an infection group(n=28)based on postoperative UTI occurrence.Clinical information,including general and laboratory data,was col-lected.Serum CRP was measured by immunoturbidimetry,Alb by bromocresol green assay,and the CRP/Alb ratio was calculated.Multivariate logistic regression was used to identify risk factors for UTI.Receiver operating characteristic(ROC)curve analysis was employed to assess the predictive value of the CRP/Alb ratio.Results Compared with the nonin-fection group,patients in the infection group are older,the infection group had a higher rate of combined diabetes,longer u-rethral catheterization indwelling time≥7 days,and longer time of operation(all P<0.05).The infection group also ex-hibited significantly higher CRP levels and CRP/Alb ratios and lower Alb levels(all P<0.05).Multivariate logistic regres-sion showed that age≥50 years(OR=2.280,95%CI:1.256-4.136),postoperative urethral catheterization indwelling time≥7 days(OR=2.846,95%CI:1.411-5.741),combined diabetes(OR=2.537,95%CI:1.533-4.198),time of operation≥77.00 min(OR=2.147,95%CI:1.344-3.430),and CRP/Alb ratio≥1.69(OR=4.389,95%CI:2.621-7.348)were independent risk factors for UTI after PCNL(all P<0.05).The areas under the ROC curve(AUCs)for CRP and Alb predicting UTI were 0.839(95%CI:0.794-0.889)and 0.742(95%CI:0.697-0.792),respectively;the AUC for the CRP/Alb ratio was 0.924(95%CI:0.874-0.969).A predictive model incorporating these risk factors achieved an AUC of 0.861(95%CI:0.811-0.906),with 66.78%specificity and 91.02%sensitivity.Conclusion Older age,pro-longed postoperative urethral catheterization indwelling time,combined diabetes,longer time of operation,and an elevated CRP/Alb ratio are risk factors for UTI after PCNL.The CRP/Alb ratio demonstrates high predictive performance for post-PCNL UTI.关键词
经皮肾镜碎石术/尿路感染/C反应蛋白/白蛋白比值/危险因素/预测价值Key words
Percutaneous nephrolithotomy/Urinary tract infection/Creactive protein/albumin ratio/Risk factors/Predictive value分类
医药卫生引用本文复制引用
陈秋梅,刘范林,刘振华,殷波,杨勇..经皮肾镜碎石术后尿路感染危险因素分析及CRP/Alb比值的预测效能[J].保健医学研究与实践,2025,22(1):74-80,7.基金项目
四川省医学科研青年创新课题项目(Q18044). （Q18044）
