海南医科大学学报2025，Vol.31Issue(8)：608-616,9.DOI:10.13210/j.cnki.jhmu.20250325.003
奶酪摄入与自身免疫性疾病的因果关系:一项两样本孟德尔随机化研究
The causal relationship between cheese intake and autoimmune diseases:A two-sample mendelian randomization study
摘要
Abstract
Objective:To investigate whether cheese intake associated with autoimmune diseases since dietary habits have been confirmed to affect autoimmune diseases.Methods:We obtained genome-wide association study data from the UK Biobank.Two-sample MR analyses were used to explore the potential causal role of cheese intake in autoimmune diseases outcome.In order to reveal the causal relationship between cheese intake and autoimmune diseases,single nucleotide polymorphisms were rigorously selected as instrumental variables.MR analysis was performed using the inverse variance weighted,MR-Egger,weighted medi-an,simple mode and weighted mode methods.To ensure the reliability of the conclusions,sensitivity analyses were indispensable and included heterogeneity testing,horizontal pleiotropy testing,leave-one-out analysis,and MR-PRESSO analysis.Results:Thirteen autoimmune diseases were included in the analysis,such as Sjogren′s syndrome,Juvenile rheumatoid arthritis,ulcerative colitis,Type 1 diabetes,systemic sclerosis,Myasthenia gravis,Rheumatoid arthritis,Systemic lupus erythematosus,Localized scleroderma,Multiple sclerosis,Autoimmune thyroiditis,Inflammatory bowel disease and Celiac disease.In terms of the expo-sure factor for cheese intake,the inverse variance weighted(IVW)showed that only three autoimmune diseases are affected by cheese intake,and the P value and odds ratio are as follows:ulcerative colitis(P=0.017,OR=0.997,95%CI=0.994-0.999),Rheumatoid arthritis(P=0.001,OR=0.993,95%CI=0.990-0.997),Localized scleroderma(P=0.009,OR=12.936,95%CI=1.904-87.894).Furthermore,this study shows that low-fat hard cheeses can aggravate rheumatoid arthritis(P=0.022,OR=1.001,95%CI=1.000 1-1.002).Conclusion:A high intake of cheese intake may be associated with a decreased risk for ulcerative colitis and rheumatoid arthritis,but with a substantial increase in risk for localized scleroderma.关键词
自身免疫性疾病/奶酪/孟德尔随机化Key words
Autoimmune diseases/Cheese/Mendelian Randomization分类
医药卫生引用本文复制引用
吴志杰,傅祥炜,张黎,李传真..奶酪摄入与自身免疫性疾病的因果关系:一项两样本孟德尔随机化研究[J].海南医科大学学报,2025,31(8):608-616,9.基金项目
This study was supported by the Hainan Province Science and Technology Special Fund(ZDYF2023SHFZ095) 海南省财政科技计划资助项目(ZDYF2023SHFZ095) （ZDYF2023SHFZ095）
