海南医科大学学报2025，Vol.31Issue(8)：628-633,640,7.DOI:10.13210/j.cnki.jhmu.20241226.003
淋巴管新生在慢性创面中的研究进展
Research progress on lymphangiogenesis in chronic wounds
摘要
Abstract
Chronic wounds(CWs)are non-healing wounds caused by a combination of factors,including microcirculatory dysfunction and persistent inflammation,posing significant challenges in its clinical management.Studies had demonstrated that lymphangiogenesis plays a critical role in the healing of CWs by promoting interstitial fluid drainage,reducing the accumulation of inflammatory cells,and accelerating the clearance of metabolic waste products.Current research highlighted the close relationship between lymphangiogenesis and the pathophysiology of CWs.Particularly in diabetic foot ulcers,impaired lymphatic function is considered a major contributor to poor healing outcomes.The regulatory mechanisms of lymphangiogenesis involve multiple path-ways and targets,including autophagy,inflammasome-mediated nonspecific immune responses,and molecules such as Tie recep-tors,LYVE-1,CCBE1,lncRNA-GAS5,miR-181a,and VEGF-C.Furthermore,modulating the activity of adipose-derived mesenchymal stem cells offers novel therapeutic strategies for CWs.Future research should focus on multifactorial interventions targeting CWs,aiming to advance the application of lymphangiogenesis in the treatment of chronic wound healing and foster its clinical application.关键词
慢性创面/淋巴管新生/炎症反应/作用机制Key words
Chronic wounds/Lymphangiogenesis/Inflammatory response/Mechanism of action分类
医药卫生引用本文复制引用
于芳宁,何秀娟,徐旭英..淋巴管新生在慢性创面中的研究进展[J].海南医科大学学报,2025,31(8):628-633,640,7.基金项目
This study was supported by the National Natural Science Foundation of China(82174388),the Fifth Batch of National Clinical Outstanding Talents of Traditional Chinese Medicine[National Office of Traditional Chinese Medicine Teaching Letter(2021)No.271],Beijing Hundred Million Talents Project Training Fund(2019A30),and Beijing Hospital Management Center"Peak"Talent Training Program(DFL20220801) 国家自然科学基金资助项目(82174388) （82174388）
第五批全国中医临床优秀人才研修项目[国中医药办人教函(2021)271号] （2021）
北京市百千万人才工程(2019A30) （2019A30）
北京市医管中心人才培养计划"登峰"项目(DFL20220801) （DFL20220801）
