广州化学2025，Vol.50Issue(2)：7-14,8.DOI:10.16560/j.cnki.gzhx.20250217
苯并吡喃腈类氰基乙烯化合物的合成研究
Studies on the Synthesis of Benzopyrannitrile-type Cyanoethylene Compounds
摘要
Abstract
The synthesis and application of cyanoethylene compounds have attracted much attention in recent years.Benzopyrannitrile,as a kind of cyanoethylene compound fused with the benzene ring,is an important synthon in organic synthesis.In this paper,15 benzopyrannitrile compounds were synthesized by dehydrating condensation reaction using cheap and readily available chromones(benzopyranones)and malononitrile as raw materials under the action of acetic anhydride and alumina.The reaction conditions were optimized and the scope of application of the substrate was observed.These synthesized compounds were well characterized by 1H-NMR,13C-NMR,19F-NMR and high resolution mass spectrometry(HR-MS).The results show that the addition of alumina in the reaction is beneficial to obtain a series of benzopyran nitrile compounds in high yield.More importantly,this method is not only suitable for benzopyranones,but also for thiobenzopyranone substrates.This new synthesis research enriches the diversity of cyanoethylene compounds and is conducive to the development of green synthetic chemistry.关键词
色酮/苯并吡喃腈/氧化铝/脱水缩合反应/氰基乙烯化合物Key words
chromone/benzopyranonitrile/alumina/dehydrating condensation reaction/cyanoethylene compound分类
化学引用本文复制引用
曹西颖,黎忠昊,于冉冉,叶蕴仪,谢佳瑜,李煌,汪朝阳..苯并吡喃腈类氰基乙烯化合物的合成研究[J].广州化学,2025,50(2):7-14,8.基金项目
广东省基础与应用基础研究项目(No.2021A1515012342) （No.2021A1515012342）
