广州化学2025，Vol.50Issue(2)：33-38,6.DOI:10.16560/j.cnki.gzhx.20250203
氧杂双环[2.2.1]桥环骨架构建方法的研究进展
Progress on Construction Method of Oxygen Heterocyclic Double Ring[2.2.1]Bridge Ring Skeleton
摘要
Abstract
This article provides a brief introduction to the structure of the oxygen heterocyclic[2.2.1]bridge ring and its natural products.It specifically introduces various methods for constructing the framework of the oxygen heterocyclic[2.2.1]bridge ring in recent years,including the synthesis of substituted epoxy compounds as precursors,the construction of free radical reactions induced by organic mercury compounds,the construction of Prins tandem cyclization,the construction of metal Lewis acid catalyzed(bismuth trifluoromethanesulfonate,transition metals)tandem reactions,and the construction of TMM cycloaddition reactions.Each method has its own shortcomings.This article summarizes various methods for constructing oxygen heterocyclic[2.2.1]bridge rings in recent years,and looks forward to the improvement direction of future methods for constructing oxygen heterocyclic[2.2.1]bridge rings.关键词
氧杂双环[2.2.1]/串联环化/金属催化/构建方法Key words
oxygen heterocyclic[2.2.1]/tandem cyclization/metal catalysis/construction method分类
药学引用本文复制引用
梅春祥,刘钊,何述钟..氧杂双环[2.2.1]桥环骨架构建方法的研究进展[J].广州化学,2025,50(2):33-38,6.基金项目
贵州省基础研究(自然科学)项目(ZK[2021]039) （自然科学）
