国际口腔医学杂志2025，Vol.52Issue(3)：296-307,12.DOI:10.7158/gjkq.2025024
间充质干细胞用于牙周再生临床疗效的系统评价与Meta分析
Clinical efficacy of mesenchymal stem cells on periodontal regeneration:a systematic review and meta-analysis
摘要
Abstract
Objective This study aimed to compare the differences in clinical attachment level(CAL),periodontal probing depth(PPD),gingival recession(GR),and bone defect depth(BDD)between patients undergoing periodontal sur-geries with and without mesenchymal stem cells(MSCs)and to evaluate the clinical efficacy of MSCs in periodontal re-generation through a meta-analysis.Methods PubMed,Cochrane Library,Embase,Scopus,CNKI,Wanfang Data,and CBM were comprehensively searched for randomized controlled studies(RCTs)about MSC therapy for perio-dontal defects in patients with periodontitis up to April 1,2024.Literature selection,data collection,and evalua-tion of bias were conducted by two researchers indepen-dently,and then data were analyzed through RevMan 5.4 software and Stata 15.1 software.Results Six studies were enrolled.The meta-analysis results showed that the ex-perimental group had more significant improvement in CAL and decrease in PPD and BDD(P<0.05).However,no signi-ficant difference was found in efficacy between the two groups in terms of GR(P>0.05).Conclusion Compared with traditional periodontal regeneration methods,the application of MSCs may have some advantages.However,potential he-terogeneity among the included RCTs and limitations on the quantity and quality of these studies necessitate cautious inter-pretation of the findings.Further high-quality RCTs with a large sample size and a multicentral character are required to prove the efficacy of MSCs in periodontal regeneration.关键词
间充质干细胞/牙周再生/牙周炎/牙槽骨丧失Key words
mesenchymal stem cell/periodontal regeneration/periodontitis/alveolar bone loss分类
口腔医学引用本文复制引用
李天元,朱彤欣,柳庆,董迎春,陈斌..间充质干细胞用于牙周再生临床疗效的系统评价与Meta分析[J].国际口腔医学杂志,2025,52(3):296-307,12.基金项目
National Natural Science Foundation of China(82401135) （82401135）
Natural Science Foundation of Jiangsu Pro-vince(BK20220199) （BK20220199）
Nanjing Health Science and Technology Development Special Fund Project(ZKX22054) 国家自然科学基金(82401135) （ZKX22054）
江苏省自然科学基金(BK20220199) （BK20220199）
南京市卫生科技发展专项资金(ZKX22054) （ZKX22054）
