国际口腔医学杂志2025，Vol.52Issue(3)：308-316,9.DOI:10.7518/gjkq.2025055
牙龈卟啉单胞菌影响血管平滑肌细胞调节性细胞死亡及表型转换的研究进展
Research progress into the effects of Porphyromonas gingivalis on regulatory cell death and phenotypic switching of vascular smooth muscle cells
摘要
Abstract
Periodontitis is a chronic inflammatory disease caused by bacterial infection.Epidemiological studies and in vivo/in vitro research have consistently demonstrated a strong association between periodontitis and an increased risk of cardiovascular diseases.Vascular smooth muscle cells(VSMCs)participate in the pathogenesis of atherosclerosis,aortic aneurysms,and vascular calcification via regulated cell death mechanisms(including autophagy,apoptosis,and pyropto-sis)and phenotypic switching.Porphyromonas gingivalis,a critical periodontal pathogen,alters VSMC biological beha-vior,not only invading VSMCs to influence their regulated cell death process but also promoting phenotypic switching characterized by proliferation,migration,and calcification.These mechanisms play pivotal roles in cardiovascular disease development.This review aims to synthesize recent re-search advances and elucidate the connections between periodontitis and VSMC-regulated cell death/phenotypic switching.Novel insights into improved prevention and treatment strategies for periodontitis and cardiovascular diseases are provided.关键词
牙龈卟啉单胞菌/血管平滑肌细胞/心血管疾病/表型转换/牙周炎Key words
Porphyromonas gingivalis/vascular smooth muscle cell/cardiovascular diseases/phenotypic switching/periodontitis分类
口腔医学引用本文复制引用
别梦瑶,周婕妤,吴亚菲,赵蕾..牙龈卟啉单胞菌影响血管平滑肌细胞调节性细胞死亡及表型转换的研究进展[J].国际口腔医学杂志,2025,52(3):308-316,9.基金项目
National Natural Science Foundation of China(81970944) （81970944）
National Natural Science Foundation of China Youth Fund(82301089) （82301089）
Research and Develop Program,West China Hospital of Stomatology,Sichuan University(RD-02-202407) 国家自然科学基金(81970944) （RD-02-202407）
国家自然科学基金青年科学基金(82301089) （82301089）
四川大学华西口腔医院探索与研发项目(RD-02-202407) （RD-02-202407）
