白藜芦醇提高试验小鼠卵子质量及胚胎发育率的促生产效应OA北大核心

To investigate the effects of resveratrol(RSV)on ovulation volume,fertilized egg development,and litter yield of mice,18 aged 3-4 weeks C57BL/6J female mice were intraperitoneally injected with pregnant horse serum hor-mone(PMSG,10 U per mouse)for hyperexcretion as a blank control group,18 mice in the experimental group were sim-ultaneously intraperitoneally injected with RSV and 18 mice in the negative control group were simultaneously injected with dimethyl sulfoxide(the volume fraction was 1％ DMSO).The number of ovulated eggs,in vitro fertilization ability of eggs,developmental ability of fertilized eggs in recipient mice,and post transplant litter rate in each group of mice were observed and analyzed.The results showed that the average number of ovulations and cleavage rate in vitro,blastocyst formation rate,implantation rate and litter rate of fertilized eggs in the uterus of recipient mice with ICR(without RSV injection)in the experimental group were(34.02±5.54),(90.37±1.84)％,(93.89±3.47)％,(68.89±4.19)％,and(51.94±3.76)％,respectively,which were significantly higher than those in the blank group and negative control group(P＜0.05).To sum up,intraperitoneal injection of RSV can significantly improve the reproduction performance and effi-ciency of experimental mice during superovulation.