扬州大学学报（农业与生命科学版）2025，Vol.46Issue(2)：32-37,6.DOI:10.16872/j.cnki.1671-4652.2025.02.005
甘草黄酮对力竭运动小鼠血清抗氧化、抗炎及免疫指标的影响
Effects of licorice flavonoids on antioxidant,anti-inflammatory and immune functions in serum of exhaustive exercise mice
摘要
Abstract
To study the effects of licorice flavonoids on antioxidant,anti-inflammatory and immune functions in exhaus-tive exercise mice through the establishment of swimming model among the mice,fifty Kunming male mice were fed for 7 days and were randomly divided into five groups:the control group(group A),the exercise group(group B),the exer-cise low-dose administration group(group C),the exercise medium-dose administration group(group D)and the exercise high-dose administration group(group E),with 10 mice in each group.Group A did not exercise.Mice in group B—E were subjected to exhaustive swimming training without load once every other day.Mice in groups C—E were dosed with 4,8 and 12 g·(kg·d)-1 of licorice flavonoid solution half an hour before exercise,and the others were received normal saline with the same dose for a total of 20 days.SOD,GSH-PX,MDA,IL-1β,IL-10,IL-6,CD3+,CD4+,NK and NKT were measured in the mice at the end of exercise.The results showed that compared with group A,MDA,IL-1 β anid IL-6 were increased,GSH-Px,SOD,IL-10,CD3+,CD4+,CD8+,CD4+/CD8+,NK and NKT were de-creased in groups B—E.Compared with group B,MDA,IL-1βand IL-6 were decreased,GSH-Px,SOD,IL-10,CD3+,CD4+,CD8+,CD4+/CD8+,NK and NKT were increased in groups C—E.Compared with group C,MDA,IL-1βand IL-6 were decreased,GSH-Px,SOD,IL-10,CD3+,CD4+,CD8+,CD4+/CD8+,NK and NKT were increased in groups D and E.Compared with group D,GSH-Px,SOD,IL-10,CD3+,CD4+,CD8+,CD4+/CD8+,NK and NKT were decreased,IL-1βand IL-6 were increased in group E.The results showed that the level of lipid peroxidation and the secretion of proinflammatory factors were increased after prolonged exhaustive exercise,which led to exercise fatigue and immunosuppression in the body of the mice.Licorice flavonoids can improve the body's antioxidant enzyme activity,inhibit the generation of free radicals,increase the secretion of anti-inflammatory factors,inhibit the secretion of pro-inflammatory factors,regulate the body's exercise fatigue,and enhance the immunity.The effect of medium-dose flavonoids was the best.关键词
小鼠/甘草黄酮/力竭运动/抗氧化/抗炎/免疫指标Key words
mice/licorice flavonoids/exhaustive exercise/antioxidant/anti-inflammatory/immune indicators分类
农业科技引用本文复制引用
谢远江,李文霞,华岩..甘草黄酮对力竭运动小鼠血清抗氧化、抗炎及免疫指标的影响[J].扬州大学学报（农业与生命科学版）,2025,46(2):32-37,6.基金项目
广西哲学社会科学项目(23FTY020) （23FTY020）
山西大学博士后科研基金资助项目(230521003) （230521003）
广西高校中青年教师科研基础能力提升项目(2023KY1414) （2023KY1414）
