国际口腔医学杂志2025，Vol.52Issue(3)：411-418,8.DOI:10.7518/gjkq.2025054
Wnt/β-catenin信号通路在味蕾发育和损伤修复中的作用
The role of the Wnt/β-catenin signaling pathway in taste bud development and injury reconstruction
摘要
Abstract
The Wnt/β-catenin signaling pathway is a major route by which mammals control embryonic development and tissue homeostasis.The taste buds,a receptor of the taste system,generate taste signals to help the body evaluate the toxicity and nutritional components of food.Thus,taste buds play a vital role in the normal metabolism of mammals.The Wnt/β-catenin signaling pathway plays a crucial regulatory role in the development and reconstruction of taste buds,coor-dinating with other signaling pathways and regulatory factors to ensure the normal development and homeostasis of taste buds and taste bud cells throughout their life cycle.This review discusses the role of the Wnt/β-catenin signaling pathway in gustatory papilla development and repair.The focus is on the Wnt/β-catenin signaling pathway's regulation of progeni-tor and precursor cell differentiation,its interaction with other pathways,and maintenance of homeostasis.New insights into the molecular mechanisms of gustatory papilla development and the prevention and treatment of taste disorders are provided.关键词
Wnt/β-catenin信号通路/味蕾/味觉细胞/发育/损伤修复Key words
Wnt/β-catenin signaling pathway/taste bud/taste cell/development/injury reconstruction分类
医药卫生引用本文复制引用
郑书豪,李梓瑕,徐欣..Wnt/β-catenin信号通路在味蕾发育和损伤修复中的作用[J].国际口腔医学杂志,2025,52(3):411-418,8.基金项目
National Natural Science Foundation of China(82370947) 国家自然科学基金(82370947) （82370947）
