扬州大学学报（农业与生命科学版）2025，Vol.46Issue(2)：90-97,8.DOI:10.16872/j.cnki.1671-4652.2025.02.012
茉莉花、柚子叶、橘叶提取物对模型反应中PhIP的抑制效果研究
Research on the inhibitory effect of extracts from jasmine flowers,pomelo leaves and orange leaves on PhIP in model reactions
摘要
Abstract
The aim of this study was to investigate the inhibitory effect of jasmine flower,pomelo leaf and orange leaf on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine(PhIP)generated in a chemical model system.The flavonoid ex-tracts of jasmine flower,pomelo leaf and orange leaf with different additive amounts were added into a chemical model system with phenylalanine and creatinine as precursors for the reaction,and UPLC-MS was used to monitor the changes of the contents of precursors,intermediate phenylglycolaldehyde and the product PhIP in the model reaction to explore the inhibitory effects.The results showed that the three extracts exerted significant inhibitory effects on the generation of PhIP,with 59.63％when orange leaf extract was added at 0.06 g,56.98％when grapefruit leaf extract was added at 0.06 g,and 53.13％when jasmine flower extract was added at 0.08 g.It was concluded that jasmine flower,pomelo leaf and orange leaf flavonoid extracts significantly inhibited heterocyclic amine PhIP in the following order:orange leaf ex tract＞pomelo leaf extract＞jasmine flower extract.关键词
植物提取物/化学模型反应体系/PhIP/抑制效果Key words
plant extracts/chemical model response system/PhIP/inhibitory effect分类
农业科技引用本文复制引用
于迪,姜东华,李优优,黄娇蓉,梁馨,周冰冰,梁雨思,孔繁磊..茉莉花、柚子叶、橘叶提取物对模型反应中PhIP的抑制效果研究[J].扬州大学学报（农业与生命科学版）,2025,46(2):90-97,8.基金项目
国家自然科学基金资助项目(32060576) （32060576）
广西中医药大学"桂派杏林青年英才"项目(2022C026) （2022C026）
广西中医药大学校级科研项目(2023MS013) （2023MS013）
广西中医药大学"桂派中医药传承创新团队"项目(2023-10) （2023-10）
农作物废弃物药用研究创新团队项目(2022A005) （2022A005）
